The present investigation presents a stochastic model for a flexible manufacturing system consisting of flexible machine, loading/unloading robot and an automated pallethandling device. We consider unreliable flexible manufacturing cell (FMC) wherein machine and robot operate under individual as well as common cause random failures. The pallethandling system is completely reliable. The pallet o...

The design of cellular manufacturing system (CMS) involves many structural and operational issues. One of the important CMS design steps is the formation of part families and machine cells which is called cell formation. In this paper, we propose an efficient algorithm to solve a new mathematical model for cell formation in cellular manufacturing systems based on cell utilization concept. The p...

• Objective: To assess the impact of a drug utilization review (DUR) alert letter program on metformin discontinuation rates in patients with a metformin claim and an absolute contraindication to metformin

Cell formation problem in Cellular Manufacturing System (CMS) design has derived the attention of researchers for more than three decades. However, use of sequence data for cell formation has been the least investigated area. Sequence data provides valuable information about the flow patterns of various jobs in a manufacturing system. This paper presents a new mathematical model to solve a cell...

For overcoming the long period of seed cultured photoautotrophically and inadequate cell supply for the inoculation of microalgae photoautotrophic cultivation, a model for the photoautotrophic culture of three Chlorella species with heterotrophic cells as seed was investigated. The model can not only take advantages of rapid cell growth in heterotrophic process for preparation of cells as seed ...

Phenotypic traits may be gained and lost together because of pleiotropy, the involvement of common genes and networks, or because of simultaneous selection for multiple traits across environments (multiple-trait coevolution). However, the extent to which network pleiotropy versus environmental coevolution shapes shared responses has not been addressed. To test these alternatives, we took advant...

Human granulocyte-colony stimulating factor (hG-CSF) cDNA was expressed in the methylotrophic yeast Pichia pastoris under the control of the alcohol oxidase (AOX1) promoter. An expression vector for hG-CSF secretion was constructed using vector pPIC9. Higher levels of hG-CSF was obtained using a P. pastoris Mut+ (methanol utilization fast) phenotype. The effects of environmental factors such as...

OBJECTIVE To investigate the impact of national implementation of age restriction on fluoroquinolone prescription in children and adolescents. METHODS Data collected from the database of Health Insurance Review and Assessment Service in South Korea, a national health insurance system to analyze fluoroquinolone prescribing practice in children and adolescents younger than 18 years, between 200...