background: in iran colorectal cancer (crc) incidence varies among various places. but we do not have any validate data that deeply explored the difference of crc in kerman province by national average. the aim of this study was to evaluate the incidence of colon cancer within a 12-year period in kerman province and to find whether the incidence of crc in kerman compared with the total incidenc...

aim : this study aimed to determinant association between rs76189946 polymorphism of egf gene and risk of colorectal cancer in an iranian population. background : colorectal cancer (crc) is the third most prevalent cancer in both genders worldwide. the determination of genetic variation becomes a new way to etiology of colorectal cancer. epidermal growth factor (egf) is a mitogen that plays an ...

objective(s): ten-eleven translocation (tet) family members have been shown to be involved in the development of many tumors. however, the biological role of the tet family and its mechanism of action in colorectal carcinogenesis and progression remain poorly understood. materials and methods:we measured the expression levels of tet family members in colorectal cancer (crc) specimens, in the co...

Colorectal cancer (CRC) is a third most common epithelial carcinoma. CRC is known to develop from the early precancerous lesion to full blown malignancy via definite phases due to cumulative mutations and aberrant methylation of number of genes. The use of serum biomarkers that is non-invasive to discriminate cancer patients from healthy persons will prove to be an important tool to improve the...

Oxidative stress is significant in numerous types of disease including cancer. To protect cells and organs against reactive oxygen species (ROS), the body has evolved an antioxidant protection system that involved in the detoxification of ROS. Single nucleotide polymorphisms (SNP) of anti-oxidative enzymes may dramatically change the activity of the encoded proteins; therefore, certain alleles ...

introduction and aims: previous reports show a high proportion of young crc patients in iran. in this study we aim to look for the clustering of colorectal cancer in families of a series of crc patients from iran. materials and methods: the family history of cancer is traced in 449 crc patients of which 112 were 45 years or younger and 337 were older than 45years at time of diagnosis. the patie...

background: colorectal cancer (crc) is the third common malignancy all over the world. modern life styles affecting nutritional habits have been providing a potential impact on crc. this study aims to assess the nutritional characteristics in crc patients of golestan province, northeast of iran. methods: all incident crc cases (n=47) in northeast of iran (2004-2005) and a matched number of heal...

colorectal cancer (crc) is a third most common epithelial carcinoma. crc is known to develop from the early precancerous lesion to full blown malignancy via definite phases due to cumulative mutations and aberrant methylation of number of genes. the use of serum biomarkers that is non-invasive to discriminate cancer patients from healthy persons will prove to be an important tool to improve the...