objective(s) alzheimer’s disease (ad) is a complex disease with multifactorial etiology. inflammation has been proven to have an important role in the pathogenesis of ad. both ccr2 and ccr5 genes expression increase in ad patients comparing to control subjects. ccr5 gene encodes a protein which is a member of the beta chemokine receptors family of integral membrane proteins. ccr5-δ32 is a genet...

background: coronary artery disease (cad) is a multifactorial and heterogenic disease. recently, genome-wide association studies have reported that rs1333040 (c/t) and rs1004638 (a/t) single nucleotide polymorphisms (snps) in the 9p21 locus have very strong association with cad. this study aimed to examine these associations in southwest of iran. methods: blood samples were collected from 200 c...

alzheimer's disease (ad) is a genetically heterogeneous neurodegenerative disease and late-onset type (load) is the most common form of dementia affecting people over 65 years old. calhm1 (p86l) encodes a transmembrane glycoprotein that controls cytosolic ca2+ concentrations and aß levels and p86l polymorphism in this gene is significantly associated with load in independent case controls in a ...

late-onset alzheimer's disease (load) is a neurodegenerative disorder and the most common form of dementia affecting people over 65 years old. alzheimer’s disease is a complex disease with multi-factorial etiology. inflammation has been approved to have an important role in the pathogenesis of alzheimer’s disease (ad). tnf-a is a main pro-inflammatory cytokine that plays an essential role in in...

Background: Lung cancer is considered as one of the most frequent cancers worldwide, and has been the cause of more than one <span style="font-variant...

Genetic pleiotropy refers to the situation in which a single gene influences multiple traits and so it is considered as a major factor that underlies genetic correlation among traits. To identify pleiotropy, an important focus in genome-wide association studies (GWAS) is on finding genetic variants that are simultaneously associated with multiple traits. On the other hand, longitudinal designs ...

The heading date is a vital factor in achieving a full rice yield. Cultivars with particular flowering behaviors have been artificially selected to survive in the long-day and low-temperature conditions of Northeast China. To dissect the genetic mechanism responsible for heading date in rice populations from Northeast China, association mapping was performed to identify major controlling loci. ...

Mother-infant interactions in rodents can be used to explore the biological basis of postnatal parental effects. There is emerging evidence from laboratory studies that variation in early life experiences can induce molecular changes in the developing brain which lead to activation or silencing of genes. These epigenetic effects may account for the stability of the effects of parenting on offsp...

In a two stage genome-wide association study (2S-GWAS), a sample of cases and controls is allocated into two groups, and genetic markers are analyzed sequentially with respect to these groups. For such studies, experimental design considerations have primarily focused on minimizing study cost as a function of the allocation of cases and controls to stages, subject to a constraint on the power t...