hbs vaccines were prepared by three different methods: 1) heat inactivation (krugman, et.al 1971)2) ammonium sulphate precipitation followed by column chromatography (sephadex g-200) 3) peg-6000 (polyethylene glycol) precipitation followed by column chromatography using sephadex g-200. their efficacy was studied in guinea pigs, and the results compared with commercial japanese vaccine (green cr...

chronic hepatitis b is still a major public health issue despite the successful prophylactic vaccination attempts. chronicity of hepatitis b virus(hbv) is mainly due to its ability to debilitate host's immune system. therefore, major measures have been taken to stop this process and help patients with chronic hepatitis b infection recover from their illness. while satisfactory results have...

background: triple-course vaccination against hepatitis b might sometimes fail to increase antibody titers or maintain it at sufficient levels. the aim of this study was to evaluate the rate of seroprotection in dental students after receiving recombinant hepatitis b vaccine.     methods: anti-hbs levels of 124 dental students who had received triple-course hepatitis b vaccines (scheduled at mo...

abstract        background and objective: aluminum salts are among the most common useful additive compounds in preparation of human and animal vaccines. aluminum phosphate and aluminum hydroxide are two additives that show good immunoadjuvant effects with many antigens. aluminum-containing vaccines lead to a better and longer immune response compared to adjuvant-lacking vaccines. the chromogen...

In accordance with its mandate to provide guidance to Member States on health policy matters, WHO is issuing a series of regularly updated position papers on vaccines and vaccine combinations against diseases that have an international public health impact. These papers are concerned primarily with the use of vaccines in large-scale immunization programmes; limited vaccination, as executed most...

During the past decade there has been extraordinary progress toward the development of vaccines for the prevention of type A and type B hepatitis. The successful propagation of hepatitis A virus in cell culture in 1979 was followed by the preparation of experimental live attenuated hepatitis A vaccines that have been shown to induce antibody in marmosets and chimpanzees and protect immunized ma...