Calcium Hydroxide (CH) is commonly employed as intracanal medicament in endodontics. In order to maximize its therapeutic effects, it is essential to develop new approaches for preparing the controlled drug release systems which, in turn, facilities the dissociation of CH into calcium and hydroxyl ions. This work studies the sustained-controlled release of calcium ions and the effect of pH chan...

Unusual self-assembly behavior is observed for a range of hydrophilic homopolymers. This self-assembly behavior is contrary to the expected behavior of such hydrophilic polymers and instead mimics more commonly reported amphiphilic block copolymers. It is proposed that the unique combination of hydrophobic end groups at both the α and ω chain end accounts for this unusual self-assembly behavior...

The purpose of this study was to investigate the influence of different hydrophilic polymers on the swelling, bioadhesion and mechanical strength of hydrocolloid wound dressings (HCDs) in order to provide an appropriate composition for a hydrocolloid wound dressing system. In this study, the HCDs were prepared with styrene-isoprene-styrene copolymer (SIS) and polyisobutylene (PIB) as the base u...

       The purpose of this review article is to characterize all of the parameters regarding the types, polymers used, and release kinetics of matrix tablets. Matrix system was the earliest oral extended release platform for medicinal use. Matrix tablets are most commonly used methods to modulate the release profile of drugs. They are much desirable and preferred for such therapy because they o...

      Losartan potassium is a well known orally active non-peptide angiotensin II receptor antagonist. Losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin II by selectively blocking the binding of angiotensin II to AT1 receptors. The drug is reported to promote the decrease in ventricular hypertrophy, salt ...

Thermolysis of a diazirine end group Br-functional PCL leads to carbene generation and subsequent hyperbranched polymers. Grafting hydrophilic PEG yields amphiphilic polymers which self-assemble into spherical core–shell nanoparticles.

Hydrogels comprises of different classes class of materials that could absorb considerable amount of water while maintaining their integrity in water having three dimensional, hydrophilic, polymeric networks. In the last few years, radical methods of preparation of hydrophilic polymers and hydrogels have evolved that may be used in the future in drug delivery applications. For successful and de...

Highly cross-linked 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) dimethacrylate with poly(ethylene glycol) of molecular weight 600 (PEG600DMA) were molecularly imprinted with hydrophilic templates glucose and proxyphylline using water as a solvent. Glucose-imprinted polymers showed increased recognitive capacity compared to nonimprinted polymers as well as increased glucose upta...

The origin of the adsorption-induced phenomena in hydrophilic polymers, such as cellulose, lies at the atomistic scale. We use molecular dynamic simulations to investigate the mechanisms by which the adsorbing polymers change their properties upon water adsorption. Despite of their limited spacial and temporal capabilities MD simulations are able to reproduce the hygroscopic swelling and moistu...