Background: Excitotoxicity is a common pathological process in neurodegenerative diseases associated with overactivity of N-methyl-D-aspartate (NMDA) and P/Q type voltage-gated calcium (Cav2.1) channels. Omega-lycotoxin-Gsp2671g is a therapeutic tool to modulate overactive Cav2.1 (P/Q type) channels. Omega-lycotoxin binds to Cav2.1 channels with high affinity and selectivity. This study aimed t...

introduction: epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory. although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. new medications with novel mechanisms of action are needed to help those patients whose sei...

Long term administration of Nicotine is capable to protect the excitotoxicity and neuronal degeneration induced by Kainic acid and it’s analogues in rodents. 16 adult male albino rats of wistar strain weighing 135-150 grams were used for the present study. The rats were divided in to four groups each consists of 4 animals. The control group was given 0.9% saline as vehicle and the experimental ...

OBJECTIVE The stimulatory and inhibitory effects of N-methyl-D-aspartic acid (NMDA) and kainic acid on prolactin (PRL) secretion have been correlated with the serum prolactin concentrations before drug administration. In the present experiments, we analysed the role of NMDA and kainic acid in PRL secretion in females with different serum concentrations of PRL. METHODS Hypoprolactinaemic femal...

3H-Muscimol, a structural analog of y-aminobutyric acid (GABA) , binds to rat brain synaptic membranes in a saturable manner, with a high affinity dissociation constant of 2.2 nM. Binding is increased in membranes that have been treated with Triton X-1Q0 and is not 3 dependent upon sodium. High affinity H-muscimol binding is regionally distributed, with highest binding density in the cerebellum...

Intraocular injection of 120 nmol. of kainic acid, a powerful glutamate receptor agonist, induces a marked degeneration of cells in the inner nuclear layer of the retina. Within 2 hours after injection there is a significant decrement in the specific activities of tyrosine hydroxylase, choline acetyltransferase, and glutamic acid decarboxylase; by 48 hours after injection there is nearly a comp...

Since picolinic acid, a tryptophan metabolite yielded by the kynurenine pathway, selectively attenuates quinolinic and kainic acid excitotoxicity that is dependent on the presence of a glutamatergic afferent input, it was hypothesized that this agent may inhibit the presynaptic release of glutamate. Using superfused rat striatal slices, this study examined the potential of picolinic acid, and r...

Background and Objective: Epilepsy is a long-lasting central nervous system disorder that is accompany with spontaneous seizures and insufficiency in learning and memory. Now drug treatment is the most common therapy but some patients do not research to suitable control of their seizures with current drugs. Hence, new treatment is needed to help those patients that are unaffected to existing dr...

introduction: temporal lobe epilepsy(tle) is a long lasting neurological disorder in which patients suffer from spontaneous seizures. new treatments with novel mechanisms of action are needed to help those patients whose seizures are resistant to available drugs. in this study, we investigated the possible neuroprotective effect of berberine in an intrahippocampal kainate model of tle in rat. m...

Introduction: Epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory. Although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. New medications with novel mechanisms of action are needed to help those patients whose sei...