Obesity has been identified as a serious health concern in domestic cats. Feline mammary cancer (FMC) is also concern, it highly prevalent and aggressive. Considering the connection between obesity breast cancer, worthwhile to investigate potential obesity–cancer relationship FMC. This review investigated association adipokines other obesity-associated molecules FMC, with aim of identifying gap...

Leptin, an adipocyte-derived cytokine (adipokine), has plethora of physiological roles in the body, particularly onset puberty, reproduction and immune function animal. Leptin binds with leptin receptor (LEPR) activates different intracellular signaling pathways to activate downstream gene expression process execute its functions. The present mini-review focuses on our current understanding abo...

Introduction:Obesity is one of the most serious challenges of our era, with significant health consequences and high economic burden for health systems. Therefore, many countries have developed political agendas to cope with this ever-rising challenge. Along with chemical medications that are developed to manage obesity, researchers have focused on some natural ingredients and herbal extracts w...

aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

background: leptin and its receptor are present in spermatozoa; however, the role of leptin in sperm function is still controversial. our present study aimed at demonstrating the effect of cryopreservation on sperm dna fragmentation (dnaf) and investigating the possible effects of sperm capacitation techniques and leptin in vitro incubation on frozen-thawed sperm dnaf and oxidative stress. meth...

Background: Leptin, the hormonal product of the obese (ob) gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety. In cattle, leptin has also been implicated in the control of ovarian function, but its local production in the ovary and role in the control of ovarian function in autocrine/paracrine manner is unknown. The aims of this study were to documen...

Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to investigate the combination therapeutic effect of these cells with insulin and metformin on neuropeptide Y, melanoco...

background: leptin is an adipokine that circulates in a free form and bound to a soluble leptin receptor. patients with polycystic ovary syndrome have increased insulin resistance and high incidence of obesity. objective: this study was carried out to evaluate levels of leptin and free leptin in women with polycystic ovarian syndrome (pcos) and note any relationships with insulin resistance and...