BACKGROUND The liver is the most frequent site of metastatic disease, and metastatic disease to the liver is far more common than primary liver carcinoma in the United States. Pathologic evaluation of biopsy samples is key to establishing a correct diagnosis for patient management. Morphologic and immunoperoxidase studies, which are the standard for pathologic practice, accurately classify most...

The liver is an important site for primary and secondary tumours. in western countries, the commonest malignant neoplasm of the liver is metastatic carcinoma, but hepatocellular carcinoma is a common and important cause of death elsewhere. There is a strong association with infection by hepatitis-B and -c; the latter explains the growing incidence of hepatocellular carcinoma in western countrie...