The lack of appropriate tumor models of primary tumors and corresponding metastases that can reliably predict for response to anticancer agents remains a major deficiency in the clinical practice of cancer therapy. It was the aim of our study to establish patient-derived tumor tissue (PDTT) xenograft models of colon carcinoma with lymphatic and hepatic metastases useful for testing of novel mol...

Cervical cancer, the fourth most common cancer among females in world, ranks second China. In advanced disease, metastases may be commonly present lungs, bones, liver and lymph nodes or elsewhere, but uncommon to skin. this report, a 63-year-old woman was diagnosed as stage IVB cervical squamous cell January 2021. The patient scheduled for concurrent chemoradiotherapy; however, metastatic lesio...

BACKGROUND This study was performed to evaluate the pattern of lymphatic metastases found by combined thoracoscopic (TS) and laparoscopic (LS) lymph node staging in esophageal cancer, and ascertain whether clinicopathologic factors may be used to guide the clinical practice of combined TS and LS staging. METHODS A retrospective study was performed in a series of 76 esophageal cancer patients ...

UNLABELLED The reliability of sentinel node biopsy is dependent on the accurate visualization and identification of the sentinel node(s). It has been suggested that extensive metastatic involvement of a sentinel node can lead to blocked inflow and rerouting of lymph fluid to a "neo-sentinel node" that may not yet contain tumor cells, causing a false-negative result. However, there is little evi...

s of Meetings Attended 2006 Gordon Conference: Molecular mechanisms in lymphatic function and disease J. Chuck Harrell, Wendy W. Dye, Carol A. Sartorius, Kathryn B. Horwitz. Department of Medicine and Program in Reproductive Sciences, University of Colorado Health Sciences Center, Aurora, CO, USA 80010 Characterizing a model of estrogen-dependent breast cancer lymphatic metastasis Background: B...

We report a young male with an initial excisional biopsy report of melanoma of the lower back, referred to our hospital for complete excision and sentinel lymph node (SLN) biopsy.  Four peritumoral intradermal Tc-99m phytate injection was performed and SLNs were detected in both axillary and right inguinal regions. On the biopsy only the right axillary SLN was metastatic leading to right axilla...

Recent molecular studies provide evidence for a significant transcriptional plasticity of tumor cell subpopulations that facilitate an active contribution to tumor vasculature. This feature is accompanied by morphological changes both in vitro and in vivo. Herein, we investigated the morphological plasticity of tumor cells with special focus on vasculogenic mimicry and neovascularisation in hum...

BACKGROUND Lymphatic metastasis is one of the leading causes of death in patients with different types of cancer and is the main prognostic factor for the disease survival. The formation of new lymphatic vessels (lymphangiogenesis) in primary tumors facilitates tumor cell dissemination to regional lymph nodes and correlates with distant metastases. Lymphangiogenesis has thus emerged as a suitab...

BACKGROUND Mediastinal lymph node sampling understages a significant number of lung cancers, even when nodes are evaluated by immunohistochemical techniques. Intraoperative lymphatic mapping and sentinel lymphadenectomy allows focused pathologic evaluation of a few lymph nodes that accurately stage the entire basin. HYPOTHESIS Lymphatic mapping and sentinel lymphadenectomy is a practical and ...

Background: Primary fallopian tube cancers (PFTCs) are rare gynecological malignancies by the prevalence of 0.3-1%. The PFTCs occur in individuals within the age range of 18-88 years, more specifically at the age range of 40-65 years with the mean age of 55 years. The PFTC usually is observed with the chronic inflammation of the fallopian tube, infertility, tuberculous salpingi...