OBJECTIVE Both methadone and buprenorphine are effective therapy for heroin dependence. Efficacy is best documented for methadone maintenance therapy, but safety concerns limit its use. Buprenorphine offers lower overdose risk and improved access, but efficacy may be lower. The authors compared adaptive, buprenorphine-based stepped care to optimal methadone maintenance treatment. METHOD This ...

background and aims: sexual dysfunction is a common complaint among drug abusers in the treatment with methadone and buprenorphine. the aim of this study was to assess sexual dysfunction in patients undergoing methadone or buprenorphine for maintenance therapy. methods: this research was a cross-sectional study. a 3-parts questionnaire (demographic questions, international index of erectile fun...

The main purpose of this research was to determine the influence a therapeutic dose an opioid drug (methadone) on selected auditory functions in patients addicted opioids (recognition ICD-10; F11) and undergoing substitution therapy. Various hearing tests were used – pure tone audiometry, impedance otoacoustic emission measurement, speech noise test two sessions, before after methadone intake. ...

AIMS Hepatitis C virus (HCV) infection is a common chronic complication of injection drug use. Methadone maintenance programs contain large numbers of patients infected with HCV. This paper reviews HCV infection with emphasis on the medical care of HCV-infected, or HCV and human immunodeficiency virus co-infected, patients on methadone or buprenorphine maintenance. METHODS Literature searches...

BACKGROUND Opioid agonist therapy using methadone, an effective treatment of opioid use disorders (OUD) for people who inject drugs (PWID), is recommended by the World Health Organization as essential to curtail the growing HIV epidemic. Yet, despite increasing prevalence of OUD and HIV, methadone therapy has not yet been implemented in Russia. The aim of this modeling study was to estimate the...

Direct Coombs’ tests (antiglobulin all of the methadone maintenance patests) were performed on blood from tients were, in fact, taking methadone, 103 opiate users prior to methadone as well as other drugs. This result maintenance therapy and 67 loncj-term conflicts with a report in which 85#{176}/o methadone maintenance patients. No of the methadone maintenance papositive tests were observed in...

Methods We evaluated HIV-infected IDUs attending an inner city clinic in Vancouver who were receiving RGV-based HAART and methadone within a directly observed therapy program. Follow-up was according to clinical standards, with changes in methadone dose being made as required to achieve clinical stabilization within the first month of HAART. The change in methadone dosing associated with the in...

background methadone effectively alleviates psychiatric disorders. objectives the aim of this study was to evaluate the effectiveness of methadone maintenance therapy in reduction of anxiety and depression among drug-abuser prisoners in ahvaz karoon’s prison. patients and methods in our interventional case-control study, 100 drug-abuser prisoners in ahvaz karoon’s prison, iran, with the symptom...