BACKGROUND Leukotrienes and isoprostanes are biomarkers of airway inflammation and oxidative stress that can be detected in exhaled breath condensate (EBC). The aim of this study was to evaluate leukotriene B4 (LTB4) and 8-isoprostane levels in EBC of healthy and asthmatic children with episodic and moderate persistent asthma. METHODS EBC was collected from 62 children aged 6 to 14 years: 22 ...

BACKGROUND Many studies in adults had identified factors associated with partly or uncontrolled asthma. In children, factors related to asthma control were not well defined. OBJECTIVE To find the factors related to partly or uncontrolled asthma in children. METHODS Asthmatic children who had severity at least in the mild persistent level, were recruited. The asthma control levels were class...

BACKGROUND In the Allergic Rhinitis and its Impact on Asthma (ARIA) classification, intermittent and persistent rhinitis were proposed to replace seasonal and perennial allergic rhinitis (AR). AIM To better understand the ARIA classification of rhinitis. METHODS A cross-sectional study was carried out in 591 patients consulting ENT or allergy specialists for AR and 502 control subjects. The...

OBJECTIVE To estimate the distribution of asthma severity in a population-based sample of children from Salvador, Brazil. METHODS An epidemiologically oriented questionnaire (International Study of Asthma and Allergies in Childhood, ISAAC) and a questionnaire based on criteria used in clinical practice (The Global Initiative for Asthma, GINA) were administered simultaneously to 417 children a...

Background: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 (IL-23) in the pathogenesis of adultallergic asthma has been studied. Objective: To explore IL...

background: il-17 is a major cytokine player in t cell mediated leukocyte associated inflammation. il-17 is also recognized to participate in the pathophysiology of asthma. objective: to determine the role of il-17 in predicting severe asthma. methods: we obtained serum samples from asthmatic children under the age of 5-year in three different groups of mild (n=33), moderate (n=28) and severe (...

BACKGROUND There are several clinical variants of severe difficult-to-treat asthma: asthma with persistent airflow limitation, brittle asthma, and fatal asthma; but the differences between the pathogenetic mechanisms underlying the disease heterogeneity are unknown. OBJECTIVES The aim was to evaluate the morphological and molecular characteristics of brittle asthma type I and asthma with pers...

OBJECTIVE To assess the dose-response relationship (benefits and harms) of inhaled corticosteroids (ICSs) in children with persistent asthma. METHODS We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that compared ≥2 doses of ICSs in children aged 3 to 18 years with persistent asthma. Medline was searched for articles published between 1950 and August 2...

Background Subcutaneous allergen-specific immunotherapy (SCIT) is a valuable treatment option for patients with controlled mild to moderate allergic asthma However, SCIT is contraindicated for patients with severe persistent asthma due to a potential systemic allergic reaction. Several studies in adolescents and adults with persistent allergic rhinitis and moderate persistent allergic asthma ha...