The angiotensin peptides that control blood pressure are released from the non-inhibitory plasma serpin, angiotensinogen, on cleavage of its extended N-terminal tail by specific aspartyl-protease, renin. Angiotensinogen had previously been assumed to be a passive substrate, but we describe here how recent studies reveal an inherent conformational mechanism is critical and release consequently p...

(Pro)renin receptor (PRR) is the recently discovered component of renin-angiotensin-aldosterone system (RAS). Many organs contain their own RAS, wherein PRR can exert organ-specific localized effects. The Binding prorenin/renin to activates angiotensin-dependent and independent pathways which leads development physiological pathological Continued progress in research suggests that upregulation ...

let g be a graph. in this paper, we study the eccentric connectivity index, the new version ofthe second zagreb index and the forth geometric–arithmetic index.. the basic properties ofthese novel graph descriptors and some inequalities for them are established.

A model for the classification of 70 HIV-1 protease crystal structure binding pockets to one of its complexed FDA approved protease inhibitors utilizing Random Forest has been developed. 456 chemical descriptors of the binding pocket of each crystal structure have been computed and are used to develop the classification model. Simulations were performed to determine the optimal Random Forest mo...

OBJECTIVES To establish how the terms recommended by the European Commission to describe side-effect risk in patient information leaflets (PILs) influences expectations of side-effects and to identify factors associated with these side-effect expectations. DESIGN A cross-sectional online survey was carried out by a market research company. SETTING Data were collected in England between 18th...

Benzimidazole derivatives, especially 2-phenylbenzimidazole with various substituents on the C-5, C-2 and C-6 positions, are so important in pharmaceutical chemistry. Multiple linear regression was applied to predict activity of 27 novel derivatives as anticancer agents. At first, we made an effort create a QSAR model for selected series density functional theory molecular docking descriptors. ...

Drug delivery by nanomaterials is an active emergent research area and CNTs draws considerable potential application owing to its unique quasi one-dimensional structure and electronic properties. Single walled carbon nanotubes and carbon fullerenes can be used in drug delivery due to their mechanical and chemical stability. The past few years, increasing attention by several reputed groups has ...