background: saponins identified from fenugreek (trigonella foenum-graecum) seeds are reported effective on dyslipidemia. however, the definite mechanism is still not elucidated systematically. in this study, we evaluate the effects of saponin extract on cholesterol absorption, metabolism, synthesis, and reverse cholesterol transport in vivo. methods: saponin extract was prepared according to a ...

the production of colony-stimulating factors (csf) is delicately controlled through a complex network of humoral and environmental factors. we have studied some of the mechanisms which regulate the production of csf as compared to general protein synthesis in the lung tissue ill vitro. when lung tissue from mice was cultured for various times in serum free medium, the first detectable level of ...

Increased cell levels of free amino acids have been found to accompany increased protein synthesis in mammalian cells under a number of conditions, including normal growth (2-6), malignancy (7, S), or in response to hormones (see (g-11), for example). The increased protein formation might result in response to the elevated cellular levels of free amino acids produced by increased active transpo...

The herpes simplex virus type 1 (HSV-1) tegument protein, VP22 has been reported to have the property of intercellular transport. The previous studies have shown that following expression of a fusion protein containing VP22 it spreads to every cell in a monolayer and concentrates in the nucleus. In spite of these reports, some studies have shown that VP22 trafficking and its nucleus accumulatio...

several transporters appear to be important in transporting various drugs. many patients, who receive morphine as analgesic medication, also receive other medications with potency of changing morphine transport by affecting p-glycoprotein (p-gp) and oatp2 transport system. this could influence morphine pharmacokinetics and pharmacodynamics. the aim of present study was to elucidate the transpor...