Radiotherapy is a major factor contributing to female infertility by inducing premature ovarian failure (POF). Therefore, the need for an effective radioprotective agent is evident. The present study investigated the mechanism of potential radioprotective effect of sodium selenite on radiation-induced ovarian failure and whether sodium selenite can stimulate in-vivo follicular development in ex...

The autometallographic retrograde tracing of zinc-containing neurons by intracerebral injection of sodium selenite (Na2SeO3), introduced by Danscher in 1982, has recently been described in more detail. Intracerebral injections of both sodium selenide (Na2Se) and sodium selenite (Na2SeO3) have been successfully used; however, sodium selenite had a rather toxic effect on the injected tissue. In t...

Background: The aim of this study was to evaluate the possible protective effect of sodium selenite on serum, liver, and kidney antioxidant enzymes activities in alloxan-induced type 1 diabetic rats. Methods: Forty Sprague-Dawley male rats were randomly divided into four groups; Group one as control, Group two as sham-treated with sodium selenite by 1 mg/kg intraperitoneal (i.p.) injections ...

Objective- This study aimed at evaluation of histopathological findings of application of chitosan- nano selenium biodegradable film on full thickness excisional wound healing in rats. Design- Experimental Study Animals- Seventy-two male Wistar rats Procedures- Animals were randomized into six groups of 12 animals each. Group I: Animals with created wounds and no...

This trial describes the effect of intraruminal infusion of sodium selenite on the in-sacco rumen degradability of a legume, Centrosema pubescens and a grass, Pennisetum purpereum in West African dwarf (WAD) sheep. A total of sixteen WAD sheep of an average body weight, 16.19 ± 2.63 kg were used for this study. A 4 x 4 Latin square design of four sheep and four sodium selenite treatments (doses...

background: the aim of this study was to evaluate the possible protective effect of sodium selenite on serum, liver, and kidney antioxidant enzymes activities in alloxan-induced type 1 diabetic rats. methods: forty sprague-dawley male rats were randomly divided into four groups; group one as control, group two as sham-treated with sodium selenite by 1 mg/kg intraperitoneal (i.p.) injections dai...

The administration of radioprotective compounds is one approach to preventing radiation damage in non-cancerous tissues. Therefore, radioprotective compounds are crucial in clinical radiotherapy. Selenium is a radioprotective compound that has been used in previous clinical studies of radiotherapy. However, evidence regarding the effectiveness of selenium in radiotherapy and the mechanisms unde...

The present investigation was performed to determine the effect of long-term administration of sodium selenite on the biochemical indices and concentration of thyroid hormones in calves. Sodium selenite solution was drenched at 0.1 and 0.25 mg per kg body weight for 12 weeks. Higher dose produced characteristic symptoms of selenosis whereas mild symptoms were observed with lower dose. The toxic...

BACKGROUND Radiotherapy of head and neck tumors often leads to acute reactions of the adjacent normal tissues resulting e.g. in mucositis and xerostomia. Therefore, radioprotective drugs have been developed to reduce these effects. Studies on a tumor model using amifostine and sodium selenite adjuvant to fractionated irradiation should show whether the radioprotective effect on normal tissue le...