background: pulmonary tuberculosis is still the most common form of tuberculosis in hiv infected patients having differ­ent presentations according to the degree of immunosuppression. this study appraised the impact of hiv infection on clini­cal, laboratory and radiological presentations of tuberculosis. methods: the clinical, laboratory and radiological presentations of pulmonary tb in 56 hiv-...

background: interferon gamma (ifn-γ), a cytokine produced by a variety of cells is involved in the immune response against m. tuberculosis. it activates the production of other cytokines and molecules that kill mycobacterium. ifn-γ also has diagnostic role in identification of active and latent tuberculosis. objective: to determine the level of ifn-γ in the blood of tb patients. methods: ninety...

tuberculous spondylitis is not an uncommon disease of the spine. near one percent of all cases of spinal tuberculosis (tb) involves craniocervical junction. hypoglossal nerve palsy is not an uncommon neurological finding, but isolated involvement of the hypoglossal nerve is rare and limited to case reports or small case series. here, we report a case of craniocervical junction tuberculosis pres...

Background: Protective immune responses induced in the majority of people infected with Mycobacterium tuberculosis enable them to control TB infection. Objective: The aim of this study was to investigate CD56 and CD16 positive peripheral blood mononu-clear cells (PBMCs) and leukocyte subsets from multi-drug resistant pulmonary tuber-culosis (MDR-TB), and compare them with nonresistant (NR) TB p...

Background: Tuberculosis (TB) is currently one of the greatest problems in public health. Mycobacterium tuberculosis infects about one third of the world's population, of whom more than 80% are living in developing countries. The incidence and prevalence of TB are very different in various parts of Iran and also throughout the world. Golestan province is one of the areas in the country where th...

Background At present of the limitation of the current case finding strategies and the global urgency to improve tuberculosis (TB) case finding, a renewed interest in active case finding (ACF) has risen. World Health Organization (WHO) calls for research on TB screening among low-income countries because of the limitation of the passive case finding strategies. We aimed to evaluated Active Case...

Background Epidemiological information on tuberculosis (TB) is required to plan control and prevention strategies and to inform service delivery systems. The aim of present study was to determine the epidemiological status of TB in Hamadan Province covering a seven-year period.   Methods In this cross-sectional study all registered TB patients suffering from any form of smear-positive, smear-ne...

objective: antigen 85 complex of mycobacterium tuberculosis includes three immunogenic proteins which are important tb vaccine candidates. the use of these protein as a component of subunit vaccines, as a part of dna vaccines or recombinant bcg boosters, enhances their recombinant production. recombinant production of these mycobacterial proteins located in the cell wall somehow differs from th...