Min-max functions, F : R → R, arise in modelling the dynamic behaviour of discrete event systems. They form a dense subset of those functions which are homogeneous, Fi(x1 + h, · · · , xn + h) = Fi(x1, · · · , xn) + h, monotonic, ~x ≤ ~y ⇒ F (~x) ≤ F (~y), and nonexpansive in the `∞ norm—so-called topical functions—which have appeared recently in the work of several authors. Our main result char...

describing drug disposition in eye compartments to simulate disposition of clonidine after topical (eye drop) administration [1]. This example extends the methodology to describe the disposition of timolol in different eye tissues and plasma after topical administration. Timolol is a nonselective beta-adrenoceptor antagonist used to lower intraocular pressure (IOP) [2]. A serious disadvantage o...

We study the support sets of sub-topical functions‎ ‎and investigate their maximal elements in order to establish a necessary and sufficient condition‎ ‎for the global minimum of the difference of two sub-topical functions‎.

HPL-BRIMS-97-13, August 1997 Dynamics of min-max functions Jean Cochet-Terrasson BPRE, Etat Major de l'Arm ee de l'Air, 24 Bd. Victor, 75015 Paris, France St ephane Gaubert INRIA, Domaine de Voluceau, 78153 Le Chesnay Cedex, France [email protected] Jeremy Gunawardena (corresponding author) BRIMS, Hewlett-Packard Labs, Filton Road, Stoke Gi ord, Bristol BS12 6QZ, UK Tel : + 44 117 922 8...

we study the support sets of sub-topical functions‎ ‎and investigate their maximal elements in order to establish a necessary and sufficient condition‎ ‎for the global minimum of the difference of two sub-topical functions‎.

niosomes are non-ionic surfactant vesicles that have potential applications in the delivery of hydrophilic and hydrophobic drugs. the topical form of n-acetyl glucosamine (nag) recently has been considered in the treatment of hyperpigmentation disorders due to its inhibitory effect on thyrosinase enzymes in melanocytes. to improve nag penetration into the skin we formulated the drug in niosomes...