Betanodaviruses, the causal agents of viral nervous necrosis in marine fish, have bipartite positive-sense RNAs as genomes. The larger genomic segment, RNA1 (3.1 kb), encodes an RNA-dependent RNA polymerase, and the smaller genomic segment, RNA2 (1.4 kb), codes for the coat protein. Betanodaviruses have marked host specificity, although the primary structures of the viral RNAs and encoded prote...

Investigation on the brain-tropism was carried out through direct injection of virus into vitreous body eye using five marine fish species: kelp grouper, striped jack, Japanese flounder, threeline grunt and yellow tail. When brains intravitreously-injected (106 TCID50 Fish-1) were examined at 72 h post infection, jack nervous necrosis (SJNNV; type species genus Betanodavirus) frequently detecte...

Produktivitas budidaya ikan kerapu cantang yang menurun salah satunya dipengaruhi oleh adanya infeksi patogen dari golongan virus dan parasit. Parasit dapat menyerang disemua stadia, sedangkan Iridovirus Viral Nervous Necrosis (VNN) merupakan penyakit serius menyebabkan kematian masal pada cantang. Tujuan penelitian ini adalah untuk memperoleh informasi kejadian pembesaran di tambak bak beton t...

Nervous necrosis virus (NNV) is the causative agent of viral encephalopathy and retinopathy (VER), a neurological disease responsible for high mortality of fish species worldwide. Taking advantage of our established Chinese perch brain (CPB) cell line derived from brain tissues of Mandarin fish (Siniperca chuatsi), the susceptibility of CPB cell to Red-Spotted Grouper nervous necrosis virus (RG...

Indonesia sebagai negara maritim yang memiliki sumber daya ikan melimpa namun tidak lepas dari berbagai infeksi jenis virus. Infeksi virus pada menyebabkan kematian akibat kerusakan multiorgan seperti nekrosis dan perdarahan. Kematian mengakibatkan kerugian ekonomi bagi para pembudidaya ikan. Kurangnya pengetahuan tentang penyakit pencehahannya menjadi salah satu faktor tingginya kasus Tulisan ...

In the present study, the effects of Chlorella vulgaris on blood and immunological parameters of Caspian salmon (Salmo trutta caspius) before and after exposure to Viral Nervous Necrosis (VNN) virus were examined. In this regard, four treatments in triplicate were chosen. Groups included one control and 3treatments (T1, T2 and T3).  Fish in control group, T1, T2 and T3 were fed diets supplement...

Multiple cell lines permissive to nervous necrosis virus (NNV) infection may be necessary for identifying receptor binding sites of viral surface protrusions. ​We have established new lines, SeGE-12, SeGE-22, SeGF and SeGB, derived from eyed-egg embryos, fin brain sevenband grouper. ​The optimum growth temperatures these were all around 30°C. temperature range SeGE-12 SeGE-22 was 25°C–32°C, whe...