Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumour in humans and is highly resistant to current treatment modalities. We have explored the combined treatment of the endoplasmic reticulum (ER) stress-inducing agent 2,5-dimethyl-celecoxib (DMC) and TNF-related apoptosis-inducing ligand (TRAIL WT) or the DR5-specific TRAIL D269H/E195R variant as a potential new strategy to...

We studied the use of dimethyl carbonate (DMC) as a non-toxic, aprotic modifier for hydrophilic liquid interaction chromatography (HILIC) and normal-phase (LC). A comparison ethyl acetate (EA) DMC organic mobile-phase modifiers in hexane LC phthalates was conducted with silica column showed that retention factors (k) at same percentage were about factor two greater DMC. Detection 215 nm, possib...

Background Independent oversight of clinical trials, recommended by Good Clinical Practice, is typically provided by an independent advisory Data Monitoring Committee (DMC) and an independent executive committee, to whom the DMC make recommendations. The detailed role and functionality of this executive committee, known as the Trial Steering Committee (TSC) have not been studied since proposed ...

Evaluation of decision-making capacity (DMC) for treatment is challenging. Owen et al, in this issue of the Journal, compare the abilities (understanding, appreciation and reasoning) relevant to DMC in medical and psychiatric patients. Here I discuss three key issues their article raises and that are relevant to the direction of future research.

Palladium containing EMT zeolite catalyst (Pd/EMT) was prepared and used for the indirect oxidative carbonylation of methanol to dimethyl carbonate (DMC). The employed as a new support compared with conventional Pd FAU (Pd/FAU). Pd/EMT in contrast Pd/FAU exhibited high intrinsic activity turnover frequency 0.25 s−1 vs. 0.11 s−1. showed CO conversion 82% DMC selectivity 79%, that maintained at l...

Digital aerial cameras have replaced analogue aerial cameras in several countries. The development for operational aerial photogrammetry started with the line scan camera ADS40, followed by Z/I Imaging DMC and Vexcel Imaging UltraCam. Recently the line scan camera Jena Optronik JAS-150 was introduced. The capacity of the UltraCam was enlarged by replacing the used CCDs with 9μm pixels over 7.2μ...