Purpose: Expression of HER2 has profound implications on treatment strategies in various types of cancer. We investigated the specificity of radiolabeled HER2-targeting ZHER2:2891 Affibody, [F]GE-226, for positron emission tomography (PET) imaging. Experimental design: Intrinsic cellular [F]GE-226 uptake and tumor-specific tracer binding were assessed in cells and xenografts with and without dr...

PURPOSE Expression of HER2 has profound implications on treatment strategies in various types of cancer. We investigated the specificity of radiolabeled HER2-targeting ZHER2:2891 Affibody, [(18)F]GE-226, for positron emission tomography (PET) imaging. EXPERIMENTAL DESIGN Intrinsic cellular [(18)F]GE-226 uptake and tumor-specific tracer binding were assessed in cells and xenografts with and wi...

BACKGROUND The radiological quality of (226)Ra, (232)Th and (40)K in some samples of water resources collected in Anarak-Khour a desertic area, Iran has been measured by direct gamma ray spectroscopy using high purity germanium detector in this paper. RESULT The concentration ranged from ≤0.5 to 9701 mBq/L for (226)Ra; ≤0.2 to 28215 mBq/L for (232)Th and < MDA to 10332 mBq/L for (40)K. The ra...

The draft genome sequences of two multiple-antibiotic-resistant Streptococcus pneumoniae isolates from Hungary, Hu15 and Hu17, are reported here. Strain Hu15 is penicillin susceptible, whereas Hu17 is a high-level-penicillin-resistant strain. Both isolates belong to the serotype 19A sequence type 226, a single-locus variant (in the ddl locus) of the Hungary19A-6 clone.

OBJECTIVE The aim of this study was to determine the prevalence rate of hepatitis A virus (HAV) and the socio-epidemiological factors affecting HAV among children aged 0-18 years in Eastern Turkey. MATERIALS AND METHODS The study sample consisted of 226 children aged 0-18 years who were registered at the Pediatrics Department of Atatürk University Medical Faculty for any reason except jaundic...

The activity concentrations of 235U, 232Th, 226Ra, 40K and 137Cs in ground and surface of drinking water resources in Iranian city of Arak were determined by gamma ray spectrometry with aHPGe detector setup, coaxial p type and 8192 channels MCA. The water samples differed in radioactivity content depending on their origin and place. In the ...

Cathepsin G is a major secreted serine peptidase of neutrophils and mast cells. Studies in Ctsg-null mice suggest that cathepsin G supports antimicrobial defenses but can injure host tissues. The human enzyme has an unusual "Janus-faced" ability to cleave peptides at basic (tryptic) as well as aromatic (chymotryptic) sites. Tryptic activity has been attributed to acidic Glu(226) in the primary ...

In this study, 226 Capsicum chinense genetic resources were analyzed using high-performance liquid chromatography and a spectrophotometer to measure compare their carotenoid content American Spice Trade Association (ASTA) color values, respectively. The total ASTA values of the pepper found be in range 7.04–2430.85 mg/100 g dry weight (DW) 0–221.32, Capsanthin, capsorubin, lutein, zeaxanthin, a...