Hepatotoxicity disorders are relatively common in patients with inflammatory bowel disease that includesulcerative colitis and Crohn’s disease. Abnormal serum liver functions tests can develop during treatment with(TNF-?) blocking agents, such as, Infliximab. The aim of this review is to clarify the role infliximab thedevelopment enzyme abnormalities most presentationof -associated injury a hep...

spinal cord injury (sci) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. the pathophysiology of acute spinal cord injury (sci) involves primary and secondary mechanisms. neuroinflammation is an important secondary injury process in sci. the local inflammatory microenvironment within the injured spinal cord ...

background and objectives: exposure to contaminated needlesticks and sharp devices is an important occupational hazard among healthcare workers. the objective of this study was to gain further insight into prevalence and risk factors of needlestick and sharps injuries among healthcare workers. methods: a cross-sectional survey was carried out among 384 healthcare workers of two hospitals in ne...

To determine the factors affecting the outcome of patients with traumatic acute subdural hematoma, we reviewed the records of7 4 consecutive comatose patients with a Glascow coma scale Score (GCS) of less than 8 who had been admitted to Imam Hosein Medical Center from 1990 to 1996 and had undergone a uniform treatment protocol. The overall mortality rate was 73% and 23% had functional reco...

Background: Thoracolumbar spinal fractures include a range of injuries of various severities from simple apophysealfractures to neurological injury and complex fractures associated with vertebral dislocation. The treatment ofthoracolumbar fractures is challenging, especially due to the difficulty of evaluating the posterior ligamentous complex(PLC). The purpose of this study w...

Spinal cord injury (SCI) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms. Neuroinflammation is an important secondary injury process in SCI. The local inflammatory microenvironment within the injured spinal cord ...

traumatic brain injury (tbi) is a global health concern that typically causes emotional disturbances and cognitive dysfunction. it elicits a complex secondary injury response, with neuroinflammation as a crucial central component. secondary pathologies following tbi may be associated with chronic neurodegenerative disorders and an enhanced likelihood of developing dementia-like disease in later...

Objective(s): Osteoarthritis (OA), characterized by degradation of articular cartilage, is a leading cause of disability. As the only cell type present in cartilage, chondrocytes play curial roles in the progression of OA. In our study, we aimed to explore the roles of miR-23b in the lipopolysaccharide (LPS)-induced inflammatory injury. Materials and Methods: LPS-induced cell injury of ATDC5 ce...