BACKGROUND Quantifying the risk of colorectal cancer for individuals is likely to be useful for health service provision. Our aim was to develop and externally validate a prediction model to predict 5-year colorectal cancer risk. METHODS We used proportional hazards regression to develop the model based on established personal and lifestyle colorectal cancer risk factors using data from 197,8...

Breast Health Day is a day that should represent the whole year and the whole life for every woman. In principle, my work as a breast surgeon (mainly clinical: I prefer the relationship I can develop with women before and after surgery) at the European Institute of Oncology, should motivate me to speak about regular checks and correct examinations, but actually I think women do not need so much...

Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 2 SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Pathology, School of Medicine, University of Colorado Anschutz Medical Campus, Denver CO Prostate and Urologic Cance...

Abstract Cyclin-dependent kinase 12 (CDK12) is a member of the CDK family proteins (CDK) and critical for cancer development. Years study into CDK12 have generated much information regarding intricacy its function mechanism as well inhibitors against it oncological research. However, there remains lack understanding role in carcinogenesis prevention. An exhaustive comprehension will highly stim...

The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) have delivered two very impressive landmark reports: the ‘determinants’ report on Food, Nutrition, Physical Activity and the Prevention of Cancer in 2007, which provides the evidence platform on the size and nature of the preventable aspects of various cancers; and the recently published ‘solutions’ report on Po...

Her clinical and research interests are in the area of breast cancer prevention, screening, diagnosis, and survivorship. She was the MD Anderson co-principal investigator (PI) on the groundbreaking Breast Cancer Prevention Trial and the STAR trial. She is currently investigating the potential role of vitamin D in breast cancer prevention. Dr. Bevers chairs the NCCN Guideline Panels for Breast C...

Biological Functions of Some Key Bioactive Compounds Grapes (Vitis vinifera L.) in the Prevention Breast Cancer: A Narrative Review

At several recent, internationally attended scientific meetings, including the American Association for Cancer Research (AACR)'s "Shaping the Future of Cancer Prevention: A Roadmap for Integrative Cancer Science and Public Health" summit in Leesburg (VA) and the AACR Annual Meeting in New Orleans, the focus on cancer prevention to reduce cancer-related deaths was extensively discussed with rene...

Saffron, the dried red-orange stigmas of Crocus sativus L, has been known as a flavoring agent, food coloring and traditional herbal medicine. Pharmacological effects of saffron are mainly attributed to crocin, crocetin, picrocrocin and safranal. These components especially crocin, have significant effects including antidepressant and anticonvulsant, analgesic, anti-cancer and other therapeutic...

BACKGROUND The National Cancer Institute (NCI) has supported implementation science for over a decade. We explore the application of implementation science across the cancer control continuum, including prevention, screening, treatment, and survivorship. METHODS We reviewed funding trends of implementation science grants funded by the NCI between 2000 and 2012. We assessed study characteristi...