Weight reduction programs usually improve the exercise capacity of patients with chronic exogenous obesity. However, the reversibility of left ventricular hypertrophy and dysfunction associated with obesity is unknown. Accordingly, an analysis was made of hemodynamic data obtained by cardiac catheterization and standard chest roentgenograms in nine markedly obese patients before and after weigh...

Most drugs are not used to treat heart disease. However, such “noncardiovascular” medications can often have cardiovascular effects. In this review, we discuss some cardiovascular manifestations of drugs used for noncardiovascular indications. We discuss these in the text according to the manifestations with which patients present; selected drugs are listed in Table 1 by their indication/drug c...

The impact of sex steroids on the cardiovascular system is of considerable importance and a potential area for therapeutic intervention. In general, animal and human studies of the vascular effects of sex hormones have suggested that oestrogen is beneficial, certain progestins may negate these effects and androgens may be potentially deleterious. In this issue of Clinical Science, Tejera et al....

The heart and lungs work closely to meet the tissues’ oxygen demands. If the balance between oxygen demand and supply becomes disturbed in critical illness, tissue hypoxia and cell death can rapidly result. An essential part of critical care is to maintain cardiopulmonary function with the help of pharmacotherapy, fluid management, and respiratory support. Paradoxically, interventions aimed at ...

The clycoxygenase (COX) enzyme forms locally active prostaglandins responsible for producing inflammation and pain. Classical non-steroidal anti-inflammatory drugs (NSAID) inhibit the COX-2 enzyme that produces inflammatory prostaglandins as well as the COX-1 enzyme that produces gastric mucosa protecting prostaglandins. By specifically inhibiting only the COX-2 enzyme, coxibs thus reduce pain ...

background : the purpose of the present study was to evaluate the effects of six-week aerobic training program including running and rope skipping on cardiovascular fitness, body mass index (bmi), and mental health among female students at the university of isfahan, iran. methods : in this interventional study we included 30 female students in academic year 2011-12. the participants were random...

Introduction: Several supra spinal areas such as rostral ventrolateral medulla (RVLM) area are involved in basic cardiovascular regulation. The Kolliker— Fuse nucleus (KF) is located in pons and is heavily connected with RVLM. The cardiovascular effect of KF nucleus has been shown and it is suggested that KF is involved in sympathetic vasomotor tone and basic cardiovascular regulation. Therefor...