conclusions the authors describe the second reported case of eptifibatide-induced severe thrombocytopenia associated with cardiac surgery. in this case, discontinuation of eptifibatide and transfusion of apheresis platelets increased the platelet count (137 k/ul) the following day, and the patient subsequently underwent successful coronary artery surgery using cardiopulmonary bypass. introducti...

quantitative relationships between structures of twenty six of 2-mercaptoimidazoles as c-c chemokine receptor type 2 (ccr2) inhibitors were assessed. modeling of the biological activities of compounds of interest as a function of molecular structures was established by means of genetic algorithm multivariate linear regression (ga-mlr) and genetic algorithm (ga-ann). the results showed that, the...

background: renal ischemia reperfusion (ir) injury has been a major source of concern during the past decades and angiotensin converting enzyme (ace) inhibitors have been successfully used to prevent this injury. there have been some controversial reports about the involvement of katp channels in the mechanism of action of ace inhibitors. in this study, we examined the effect of katp channel bl...

Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth factor receptor family having tyrosine kinase activity. Overexpression of HER2 usually causes malignant transformation of cells and is responsible for the breast cancer. In this work, the virtual screening, molecular docking, quantum mechanics and molecular dynamics methods were employed to study protein–ligand ...

Gastro-esophageal reflux disease (GERD) regularly occurs when stomach acid moves up from the stomach into the esophagus. GERD might be associated with chronic asthma symptoms such as coughing and breathlessness. According to several studies on children and adults, GERD is proven to have a close relationship with asthma.  Medication treatment via proton-pump inhibitors (PPIs), such as Omeprazole,...

The important role of the P2Y12 receptor in amplification of platelet activation and associated responses and the limitations associated with clopidogrel therapy have led to the development of novel inhibitors of this receptor. Three reversibly-binding P2Y12 inhibitors are in phase 3 development, ticagrelor, cangrelor and elinogrel. The pharmacology and clinical trial data for each of these inh...

Psychological and pharmacological modalities have been proposed by studies to be adapted for treatment of panic disorder. Selective Serotonin Receptor Inhibitors (SSRI), a group antidepressant is the first-line drug recommended National Institute Health Care Excellence (NICE) British Association Psychopharmacology their more desired profile adverse effect over other classes antidepressants such...

The treatment of patients with prostate cancer, who do not qualify for the radical therapy is based on use surgical or pharmacological castration methods. effectiveness so-called androgen deprivation tends to decrease over time. Even in absence distant metastases imaging studies, resistance hormonal may be developed. At this moment, new generation receptor inhibitors reduce risk death. paper pr...

atrial fibrillation (af) is the most common complication of coronary artery bypass graft surgery (cabg). the reported incidence of af after cabg varies from 20% to 40%. postoperative af (poaf) is associated with increased incidence of hemodynamic instability, thromboembolic events, longer hospital stays, and increased health care costs. a variety of pharmacological and nonpharmacological strate...