The study by Jimenez-Solem, along with 2 other important cohort studies (1, 2), provide reasonable data to guide SSRI medication choice for this population. Based on the existing evidence, paroxetine should definitely be avoided. Its use has been associated with congenital, especially cardiac, malformations (1, 2). One could also make a tentative case to be cautious about using citalopram, and ...

OBJECTIVE To describe the trends in the utilization and expenditures of selective serotonin reuptake inhibitors (SSRIs) and venlafaxine within the Texas Medicaid program in 1999 and 2000; more specifically, to compare the use of citalopram with other SSRI agents and venlafaxine. METHODS A retrospective analysis of Texas Medicaid paid prescription claims data involving Texas Medicaid clients a...

background: premature ejaculation (pe) is the most common sexual dysfunction compliant in about 35-40% of men younger than 40 years; therefore a study for survey and diagnosis of this disorder is very important. objective: in this study the efficacy of 2 drugs (fluoxetine and citalopram) for treatment of patients suffering from pe is compared. we studied the effectiveness of both drugs in pe wi...

In the present study we investigate the fate of citalopram (CIT) at neutral pH using advanced water treatment technologies that include O(3), ClO(2) oxidation, UV irradiation and Fenton oxidation. The ozonation resulted in 80% reduction after 30 min treatment. Oxidation with ClO(2) removed>90% CIT at a dosage of 0.1 mg L(-1). During UV irradiation 85% reduction was achieved after 5 min, while F...

Some evidence would indicate that a serotonergic deficit may be involved in epileptogenesis. A preliminary trial of citalopram, a selective inhibitor of serotonin reuptake, was carried out. Citalopram 20mg/day was given to 11 non-depressed patients with poorly controlled epilepsy as an add on treatment with an open label design for 8-10 months. The median seizure frequency dropped by 55.6% in t...

BACKGROUND We sought to determine whether clinical response or tolerance to the Selective Serotonin Reuptake Inhibitor (SSRI) citalopram is associated with genetic polymorphisms in potentially relevant pharmacokinetic enzymes. METHODOLOGY We used a two-stage case-control study design in which we split the sample of 1,953 subjects from the Sequenced Treatment Alternatives to Relieve Depression...

Introduction Management of refractory shock in the setting overdose can be challenging. We describe a case vasodilatory and cardiogenic after bupropion citalopram overdose. Vasopressors conventional therapies failed to stabilize patient resulting placement venoarterial extracorporeal membrane oxygenation (VA ECMO) for rescue recovery.Case summary: A 23-year-old male presented intentional He dev...

BACKGROUND Meta-analyses suggest that reboxetine may be less effective than other antidepressants. Such comparisons may be biased by lower adherence to reboxetine and subsequent handling of missing outcome data. This study illustrates how to adjust for differential non-adherence and hence derive an unbiased estimate of the efficacy of reboxetine compared with citalopram in primary care patients...