Multiple sclerosis (MS) is an autoimmune disease which affects myelin in the central nervous system (CNS) and leads to serious disability. Currently available treatments for MS mainly suppress the immune system. Regenerative medicine-based approaches attempt to increase myelin repair by targeting endogenous progenitors or transplanting stem cells or their derivatives. Fingolimod exerts anti-inf...

Background: The rapid diffusion of Novel Psychoactive Substances (NPS) constitutes an important challenge in terms of public health and a novelty in clinical settings, where these compounds may lead to erratic symptoms, unascertained effects and multi-intoxication scenarios, especially in emergency situations. The number of NPS available on the illicit drug market is astonishing: official repor...

Japanese speakers start interpreting sentences even before the clause-ending predicate is read or heard. We report two questionnaire studies that suggest that the possible semantic relations between NPs are critical in determining the interpretations pursued. Although the properties of individual NPs such as animacy are important, interpretation is modulated by the relations that may hold betwe...

background : incidence of  white  spots due  to  demineralization of  enamel  and  gingival problems  is  an  unacceptable  result  of  orthodontic  treatment.  plaque  accumulation  and bacterial biofilm growth are responsible for these phenomena. the resin-based dental composites used as bonding agents in orthodontics play a major role in mentioned problems. as recent researches assert the an...

The paper presents a description of a hierarchically structured recommender system for improving the efficiency of a company’s growth engine. Our dataset (NPS dataset) contains answers to a set of queries (called questionnaire) sent to a randomly chosen groups of customers. It covers 34 companies called clients. The purpose of the questionnaire is to check customer satisfaction in using service...

BACKGROUND There is no consensus about whether higher professional education (HPE) is necessary for general practitioners (GPs) to complete their vocational training. AIM To investigate beliefs about the need for HPE, its funding, duration, curriculum, and whether new principals (NPs) are eligible to undertake it. METHOD A confidential postal questionnaire was sent to senior partners, GP re...