Objective(s): The prognosis of osteoporosis is very poor, and it is very important to identify a biomarker for prevention of osteoporosis. In this study, we aimed to identify candidate markers in osteoporosis and to investigate the role of candidate markers in osteogenic differentiation. Materials and Methods: Using Weighted Gene Co-Expression Network analysis, we identified three hub genes mig...

Graph Neural Networks (GNNs) draw their strength from explicitly modeling the topological information of structured data. However, existing GNNs suffer limited capability in capturing hierarchical graph representation which plays an important role classification. In this paper, we innovatively propose capsule network (HGCN) that can jointly learn node embeddings and extract hierarchies. Specifi...

The most common malignant neoplasm of the head and neck region is laryngeal cancerwhich presents a significant international health problem. The present study aims to screenpotential proteins related to laryngeal cancer by network analysis to further understandingdisease pathogenesis and biomarker discovery. Differentially expressed proteins were extractedfrom literatures of laryngeal cancer th...

Introduction The Airline Deregulation Act (ADA) of 1978 caused many changes in the industry. For the first time in 40 years, new airlines were permitted to enter the industry, and all airlines could choose the routes they would serve and the fares they would charge. Airlines were also free to exit the industry (go bankrupt), if they made poor choices in these matters. Naturally, this has led to...

 We introduce a dynamic and stochastic transportation problem consisting of two subproblems. For parcel transportation in hub-and-spoke networks, swap containers are used to carry out hub-to-hub shipments. This constitutes a pickup and delivery problem on the operational level. On the tactical level, empty swap containers are balanced over the hub-network in order to match the stochastic deman...

Centralizing and using proper transportation facilities cut down costs and traffic. Hub facilities concentrate on flows to cause economic advantage of scale and multimodal transportation helps use the advantage of another transporter. A distinctive feature of this paper is proposing a new mathematical formulation for a three-stage p-hub location routing problem with simultaneous pick-ups and de...

We propose a novel hub location model that jointly eliminates some of the traditional assumptions on structure network and discount as result economies scale in an effort to better reflect real-world logistics transportation systems. Our extends literature various facets: instead connecting nonhub nodes directly nodes, we consider routes with stopovers; pairs hubs directly, design can visit sev...