Cell surface HLA-I molecules (Face-1) consist of a polypeptide heavy chain (HC) with two groove domains (G domain) and one constant domain (C-domain) as well light chain, B2-microglobulin (B2m). However, HCs can also independently emerge unfolded on the cell without peptides B2m-free HC monomers (Face-2), homodimers (Face 3), heterodimers (Face-4). The transport these HLA variants from ER to wa...

Host genetic factors play a central role in determining the clinical phenotype of human diseases. Association between two polymorphic loci in human genome, human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptors (KIRs), and genetically complex infectious disease, particularly those of viral etiology, have been historically elusive. Hence, defining the influence of genetic di...

Objective(s): Juvenile idiopathic arthritis (JIA) is one of the most common chronic rheumatic diseases in children. The complex nature of this immune-mediated disease owes itself to several predisposing genes and environmental factors affecting its pathogenesis. Conducted in Iran, this study was originally intended to investigate every possible association between HLA DRB1 alleles and a suscept...

Background: Multiple sclerosis (MS), as a multifactorial autoimmune disease with complex genetic basis, causes demyelination in the central nervous system via cytokine responses to myelin antigens. Myelin basic protein (MBP) is the main protein component of the myelin sheath. HLA-DRB (human leukocyte antigen-DR beta) alleles, particularly HLA-DRB1*1501, may be of significance in the pathogenesi...

The current coronavirus disease 2019 (COVID-19) pandemic that is caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) has a significant threat to public health. Although vaccines based on mRNA of SARS-CoV-2 spike protein have been developed induce both cellular and humoral immunity against SARS-CoV-2, there some concerns raised about their high cost, particularly in developing countri...

objective: this study aimed to investigate the association between hla alleles and visceral leishmaniasis (vl) in a sample of iraqi patients. methods: a total of 30 patients were studied, in addition to 20 age, gender and ethnicity matched controls. all subjects were genotyped by polymerase chain reaction-sequence specific primers (pcr-ssp) method. results: for hla-class i region (a and b loci)...

introduction systemic lupus erythematosus (sle) is a complex autoimmune and inflammatory disease. many studies show hla alleles can be associated with sle. the aim of this study was to determine the association of hla-drb1 alleles with juvenile- onset in iranian children. materials and methods at a case – control study, 31 children with systemic lupus erythematosus (case group) who referred to ...