By means of Langevin dynamics simulations, we investigate the gel formation randomly functionalized polymers in solution, with ability to form both intra- and intermolecular reversible bonds. Under highly dilute conditions, these soft nano-objects (so-called single-chain nanoparticles, SCNPs), resulting from purely intramolecular cross-linking reactive functional groups. Here show that competit...

In this commentary, we establish a relationship between medical sociology and the study of medical tourism and cross-border healthcare by introducing Ronald Andersen’s behavioral model of healthcare use, and linking this model to the recent empirical study of Kovacs et al. on patients travelling to Hungary for orthopedic treatment. Finally, we plead for more measurement in the field of patient ...

HIV-1 integrase binds site-specifically to the ends of the viral cDNA. We used two HIV-1 integrase-DNA cross-linking assays to probe the binding sites of integrase inhibitors from different chemical families and with different strand transfer selectivities. The disulfide assay probes cross-linking between the integrase residue 148 and the 5'-terminal cytosine of the viral cDNA, and the Schiff b...