traumatic retrolisthesis is a rare injury and may result in intervertebral disc extrusion and nerve root injury. these injuries are highly unstable and require surgery for decompression and stabilization. traumatic retrolisthesis of l5 with acute l5/s1 disc extrusion associated with nerve root injury has not been reported previously in english literatures. we herein report a case of traumatic r...

Introduction: Pharmacological blockage of glial activity has been proved useful for treatment of neuropathic pain by lowering proinflammatory cytokines. The present study is to confirm the effect of post-injury administration of pentoxifylline on chronic constriction injury (CCI)-induced neuropathic pain symptoms_ and improved the efficacy of morphine anti-nociception. Methods: Male Wistar ...

To explore the analgesic effect of electro-acupuncture on neuropathic pain model rats and to clarify mechanism analgesia from perspective vesicular glutamate transporter 2/toll like receptor 4 signal pathway. A total 30 specific pathogen free grade adult male Sprague-Dawley were selected. The randomly divided into group (chronic constriction injury), sham operation group, non-electro-acupunctur...

Schwann cells undergo phenotypic modulation in peripheral nerve injury. In the adult rodent, Schwann cells are resistant to death-promoting challenges. The responsible receptors and signaling pathways are incompletely understood. In this study, we demonstrate that low-density lipoprotein receptor-related protein-1 (LRP-1) is expressed in adult sciatic nerve. After crush injury, LRP-1 is lost fr...

Background & Aims: Peripheral nerve injuries affect both sensory and motor function, resulting in retrograde reaction to neuronal cell bodies in the ventral horn of spinal cord ventral and their destruction. Achillea wilhelmsii is one of the popular medicinal herbs which grow in dry and semitropical areas worldwide. There are several reports indicating the anti-inflammatory, antispasmodic, anti...

The present study was performed to investigate the effects of long-term intraperitoneal (IP) injection of vitamin B12 and diclofenac in separate and combined treatments on cold and mechanical allodynia in a neuropathic pain model in rats. Neuropathic pain was induced by crush injury in right tibial nerve. Acetone spray and von Frey tests were used to obtain cold and mechanical allody...

In the spinal dorsal horn (DH), nerve injury activates microglia and induces neuropathic pain. Several studies clarified an involvement of adenosine triphosphate (ATP) in the microglial activation. However, the origin of ATP together with the release mechanism is unclear. Recent in vitro study revealed that an ATP marker, quinacrine, in lysosomes was released from neurite terminal of dorsal roo...

Objectives: Injury of lingual nerve is a rare complication general anesthesia. The causes injury following anesthesia are multifactorial; possible mechanisms may include difficult laryngoscopy, prolonged anterior mandibular displacement, improper placement the oropharyngeal airway, macroglossia and tongue compression. Case Report: A case atypical neuralgia that was associated with orotracheal i...