As the incidence and already high mortality rates of malignant melanoma have been steadily increasing in recent decades, the early detection and excision of malignant melanoma have imposed as the most important task. Staging of malignant melanoma is determined according to the level of invasion (Clark level) and vertical thickness (Breslow scale). Besides operative therapy, which is the only ef...

Ionotropic glutamate receptors (iGluRs) are large integral membrane multi-protein complexes that create ion channels in plasma membranes. Upon binding of receptor specific ligands (e.g., glutamate), increased efflux or influx of mono- or divalent cations (e.g., Ca2+) promotes synaptic transmission, cellular migration, and survival. Three classes of iGluRs were originally defined after their res...

Background: Malignant skin tumors are of the most common types of cancers worldwide. Rafsanjan County, Iran, is geographically located in a warm and arid area. In addition, due to farming activity, a large population of this county is exposed to sunlight. The present study aimed at to determine factors associated with malignant skin tumors among patients referred to Ali-ibn Abi Talib Hospital, ...

Anorectal malignant melanoma is a very rare but lethal disease. Patients with anorectal malignant melanoma commonly complain for changes in bowel habits and rectal bleeding. Therefore, anorectal malignant melanoma is often misdiagnosed as hemorrhoids, polyp or rectal cancer. Surgery is the mainstay of treatment for patients with anorectal malignant melanoma. However, whether abdominoperineal re...

BACKGROUND Epidemiological studies evaluating the association between sunscreens use and malignant melanoma risk have produced inconsistent results. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of sunscreens use with the risk of malignant melanoma. METHODS Pertinent studies were identified by a search in PubMed and Web of Knowledge up to October 20...

  Periarticular cyst and cystic soft tissue lesion around the knee are common. Synovial sarcoma is a rare and malignant soft tissue tumor accounting for approximately 5% of soft tissue sarcoma. A case is presented where a lesion adjacent to the joint line of the knee was diagnosed clinically and on imaging as a meniscal cyst. MRI signal was homogenous and no concomitant meniscal tears were seen...

Careful study of capillary endothelial cells as part of the stroma reaction in human malignant melanoma showed branched tubular structures (BTS). These structures were found in five cases, two of which were melanoma superficial spreading type with strong host cellular response (level 2 invasion), and one of which was a nodular melanoma (level 3 invasion) associated with a good host-cellular TAB...

To the Editor: In the 1st issue of HJNM for 2012 we read with interest a case where 3 different cancers were detected [1]. Synchronous second malignancy can be incidentally detected in routine fluorine-18-fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/ CT) imaging in approximately 1% of cancer patients with lungs being the most frequent site [2]. We report th...