Results: In total, 40 patients were enrolled; median follow-up was 41 months. The majority of patients were clinical stage III (n=37, 92.5%), ≥ 50 year (n=34, 85%), and male gender (n=29, 72.5%). Approximately half of the patients had laryngeal cancer. The overall grade 3 acute toxicity was 62.5%; mainly mucositis (n=23, 57.5%) and dysphagia (n=18, 45%). Overall, 34 patients (85%) showed comple...

We have demonstrated that the DNA sequence between two triplex-forming polypurine.polypyrimidine (Pu.Py) tracts was protected from DNA modifying enzymes upon formation of triplex DNA structures with an oligodeoxyribonucleotide in which two triplex-forming Pu or Py tracts were placed at the termini (triplex-bridge formation). In model experiments, when two triplex structures were formed between ...

A bioactive biotin-containing derivative of the synthetic bovine parathyroid hormone analog [Nle8,Nle18,Tyr34]bovine parathyroid hormone-(1-34) (bPTH-(1-34] amide was prepared by reacting the peptide with N-biotinyl-epsilon-aminocaproic acid N-hydroxysuccinimide ester. The derivative was incubated with particulate renal plasma membranes or with detergent [3-[(3-cholamidopropyl)dimethylammonio]-...

the c3 phenotypes were determined by high-voltage agarose gel electrophoreses in german patients suffering from lymphosarcoma (n=34), hodgkin (n=59) and a group of other haematological diseases (n=46). frequencies of c3 ss, sf and ff pho=enotypes were not significantly different from the frequencies found in a control group of 322 healthy germans. however, high frequency of the ff phenotype in ...

Sergio Castiñeira-Ibáñez 1, Daniel Tarrazó-Serrano 2, Constanza Rubio 2,*, Pilar Candelas 2 and Antonio Uris 2 1 Departamento de Ingeniería Electrónica, Universitat de València, Avd. de la Universitat s/n, Burjassot, Valencia 46100, Spain; [email protected] 2 Centro de Tecnologías Físicas, Universitat Politècnica de València, Camino de Vera s/n, Valencia 46022, Spain; [email protected] (D.T.-S.); ...

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3 Department of Anatomy, Cellular Biology and Zoology, University of Extremadura Avda. de Elvas s/n, ES-06006, Spain *These two authors contributed equally to this work Corresponding author: Luz Garcia-Longoria, Department of Anatomy, Cellular Biology and Zoology, University of Extremadura Avda. de Elvas s/n, ES-06006, Spain. Tel: (+34) 924289412, fax (+34) 924289417. E-mail: luzlongoria@unex D...