نتایج جستجو برای: transcriptional regulation
تعداد نتایج: 610184 فیلتر نتایج به سال:
Background: Bispecific antibodies represent an important class of mAbs, with great therapeutic potentials due to their ability to target simultaneously two distinct epitopes. The generation of functional bispecific antibodies with the highest possible yields is particularly critical for the production of these compounds on industrial scales. Anti- CD3 × CD19 bsAb is a bispecific T-cell engager ...
Differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. A number of studies have reported the effects of biochemical modifications of chromatin (DNA and chromatin proteins) on the regulation of transcription. Although, these studies are able to explain how transcription of a given gene is regulated (toward activation...
Background and purpose: LncRNAs are a group of non-coding RNAs with more than 200 nucleotides involved in transcriptional and post-transcriptional regulation of gene expression, that have a potential role in diagnosis, prevention and treatment of some disorders such as cancers. There is paucity of information about their involvement in hemophilia disease. This study aimed at discovering the rel...
Abstract Wnt signaling plays pivotal roles during our entire lives, from conception to death, through the regulation of morphogenesis in developing embryos and maintenance tissue homeostasis adults. The occurs on several levels: at receptor level plasma membrane, β‐catenin protein cytoplasm, transcriptional nucleus. Several recent studies have focused mechanisms regulation, following discovery ...
Long regulatory elements (LREs), such as CpG islands, polydA:dT tracts or AU-rich elements, are thought to play key roles in gene regulation but, opposed conventional binding sites of transcription factors, few methods have been proposed formally and automatically characterize them. We present here a computational approach named DExTER (Domain Exploration To Explain Regulation) dedicated the id...
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