BACKGROUND New tumor markers and markers of tumor progression are needed for improved staging and for better assessment of treatment of many cancers. Gene expression profiling techniques offer the opportunity to discover such markers. We investigated the feasibility of sample pooling strategy in combination with a novel analysis algorithm to identify markers. METHODS Total RNA from human colo...

BACKGROUND The effectiveness of tumor markers in evaluating outcomes of patients with hepatocellular carcinoma (HCC) remains to be clarified. SUMMARY The usefulness of the HCC tumor markers, alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3), and des-gamma-carboxy prothrombin (DCP) was reviewed. Elevations in these tumor markers at the time of H...

Angiogenesis is a hallmark of solid tumors, and disruption of tumor vasculature is an active anticancer therapy in some cases. Several proteins expressed on the surface of tumor endothelium have been identified during the last decade. However, due to the expression in both physiological and tumor angiogenesis, only a few targets have been developed for clinical therapeutics. By thorough SAGE an...

The term tumor markers include a spectrum of molecules and substances with widely divergent characteristics whose presence in the significant amount can be related to the malignant disease. An ideal tumor marker should have high specificity and sensitivity, which would allow its use in early diagnosis and prognosis of malignant disease, as well as in prediction of therapeutic response and follo...

Abstract Regulatory T cells (Treg) are one of the major impediments to effective antitumor immunity and successful immunotherapy. Elevated intratumoral Treg frequencies, observed in a variety malignancies, have been associated with poor prognosis. In this issue Cancer Research, two studies underscore potential harnessing unique migratory profile tumor-infiltrating Tregs selectively eliminate th...

nonfunctional adrenocortical carcinoma is an extremely rare malignant tumor in children. unlike the functional tumor which is detected early due to its hormonal presentation, nonfunctional tumor is detected at a later stage. here we report a case of a 10 year old girl who presented with abdominal mass and symptoms of short duration. no hypertension and cushingoid features were seen. serum alpha...

Reduce cost of care An obvious goal is to enhance patient care. We have to remember that tumor markers are not treatments and that the relevance of tumor markers for particular cancers are only as good as the treatments allow them to be. The other speakers have made that observation also. So how can tumor markers enhance patient care? Hopefull~ they can extend survival time and improve the qual...

Study objectiveThe aim of this study is to examine the importance tumor markers in diagnosis adnexal masses pediatric and adolescent gynecology.Materials methodsRelevant studies published over last 20 years were identified by a PubMed/Medline search using different combinations following terms: “tumor markers”, “adnexal masses” “pedaitric gynecology”. Additional papers reviewing reference lists...

The pursuit of the ideal tumor marker has generated many tests for use in the diagnosis and management of cancer, several of which are now widely available. Tumor markers have five potential uses in patient care: They can be used for screening, for diagnosis, for establishing prognosis, for monitoring treatment, and for detecting relapse. The value of a marker in a given setting depends on two ...