کچ ي هد دنب هعطق شور كي هلاقم نيا رد ي واصت ي گنر ر ي هقبط زا هدافتسا اب ريگداي ياتاموتا رب ينتبم يزاف هدننک يدنب م داهنشيپ يلولس ي ددرگ . نيا رد هقبط نيناوق و تيوضع عباوت يلولس ريگداي ياهاتاموتا زا يا هعومجم كمك هب هدننک يدنب يم ديلوت کيتاموتا روط هب يزاف دنوش . ا يلولس ريگداي ياتاموتا ز نِگمه ان مِاگمهان هب زاب نيرتهب نتفاي يارب يرازبا ناونع تسا هدش هدافتسا يزاف تيوضع عباوت راتخاس . رد اتاموت...

Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the adjuvant effect of murine CpG ODN 1826 on the immunogenicity and protective efficacy of the Saccharomyces cerevisiae-expressed 19-kDa C-terminal region of merozoite surface protein 1 (yMSP1(19)) of the...

Earthworms were collected in forests, damp habitats, springs, orchards and agricultural fields of the Kohgiluyeh & Boyer Ahmad Province, Iran, from April 2009 to April 2010. Specimens were collected at 20 established stations by digging and by diluted formalin methods. Ten species belonging to family Lumbricidae were identified based on morphology: Aporrectodea caliginosa (Savigny, 1826), Ap. r...

Mucin 1 (MUC1), being an oncogene, is an attractive target in tumor immunotherapy. Maltose binding protein (MBP) is a potent built-in adjuvant to enhance protein immunogenicity. Thus, a recombinant MUC1 and MBP antitumor vaccine (M-M) was constructed in our laboratory. To enhance the antitumor immune activity of M-M, CpG oligodeoxynucleotides 1826 (CpG 1826), a toll-like receptor-9 agonist, was...

During a 200 ks observation with the XMM-Newton Reflection Grating Spectrometer, we detected 16 typeI X-ray bursts from GS 1826–24. We combined the burst spectra in an attempt to measure the gravitational redshifts from the surface of the neutron star. We divided the composite GS 1826–24 burst spectrum into three groups based on the blackbody temperature during the bursts. The spectra do not sh...

Synthetic oligodeoxynucleotides containing unmethylated CpG motifs detected by Toll-like receptor 9 of dendritic cells and B cells have potent immunomodulatory effects. CpG oligodeoxynucleotides induce cytokines, activate natural killer cells, and elicit T-cell responses leading to antitumor effects, including improved efficacy of chemotherapeutic agents and, as we reported recently, synergy be...