نتایج جستجو برای: bupropion reserpine
تعداد نتایج: 3330 فیلتر نتایج به سال:
Abstract:Purpose:This study was designed determine the efficacy of bupropion versus placebo in subjects with negative symptoms of schizophrenia.Methods:A convenience sample of 40 patients of both genders aged 18-60 years who were living in psychiatric care centers were randomly treated with bupropion (started with 75 mg twice a day; increased to 100 mg thrice daily) or placebo. The diagnosis of...
introduction: the most common interpretation for the mechanisms of antidepression is the increase of the brain monoamine levels such as dopamine (da). the increase of da can reduce depression but it can also decrease the monoamine release because of autoreceptor inhibition. although bupropion can decrease the dopamine release, there is evidence about stimulatory effects of chronic application o...
Introduction: Due to severe burden of depressive disorders and a low rate remission in patients receiving antidepressant therapy, there is an urgent need for developing novel agents with action fundamentally new mechanism action. 3-ethoxythietane-1,1-dioxide (N-199/1) molecule that showed significant properties when administered intraperitoneally once or repeatedly. The aim the present study wa...
OBJECTIVES To assess potential infant exposure to bupropion and its active metabolites in breast milk such as would occur during treatment to prevent post-partum relapse to tobacco use, and to compare the concentrations of bupropion in urine and saliva with plasma and breast milk. DESIGN AND SETTING Cohort study, outpatient clinical research centre. SUBJECTS Ten healthy post-partum voluntee...
antidepressants are widely used for the treatment of various neuropathic pain conditions in humans. recent studies have demonstrated that bupropion is effective for the treatment of neuropathic pain. also antidepressants like bupropion showed anti-inflammatory properties. so in the present study, the analgesic and anti-inflammatory effects of bupropion in mice and rat were investigated. the ace...
Background and purpose: Decreasing the quality of life in cancer patients is an essential factor that influences their lives during the process of treatment and after that. A lot of studies have been done to evaluate the efficacy of medical agents on quality of life. In this study, we evaluate the efficacy of Bupropion as an antidepressant agent in quality of life of cancer patients. Materials...
The atypical antidepressant bupropion has been shown to be an efficacious smoking cessation agent; however, its therapeutic mechanism of action is unknown. To further understand the mechanism by which bupropion reduces smoking, the present study determined the effect of repeated bupropion pretreatment on nicotine self-administration or sucrose-maintained responding. Rats were trained to self-ad...
The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing heterologously expressed human cytochromes P450 (CYP). The mean (+/-S.E.) K(m) in four human liver microsomes was 89 (+/-14) microM. In microsomes containing cDNA-expressed CYPs, hydroxybupropion formation was mediated only by CYP2B6 at 50 microM bupropion (K(m) 85 mic...
This study was conducted to evaluate the effect of bupropion sustained-release (SR) on smoking cessation in patients with chronic posttraumatic stress disorder (PTSD). Fifteen veterans with chronic PTSD who desired to stop smoking enrolled in a 12-week double-blind evaluation of bupropion SR and placebo. Patients were randomly assigned in a 2:1 ratio to receive either bupropion SR or placebo. B...
BACKGROUND Bupropion, which is widely used in patients with depressive disorder, may cause allergic reactions. However, the real prevalence of these side effects may be overlooked and underreported due to the delayed onset phenomenon. OBJECTIVE This study aimed to estimate the real incidence of bupropion-induced urticaria and clarify the delayed onset phenomenon. METHODS We conducted a nati...
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