INTRODUCTION In the current study, the protective effect of hesperidin (HP) on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats was investigated. MATERIAL AND METHODS Twenty-eight rats were divided equally into four groups. The first group was kept as a control and given only vehicle. In the second, rats were orally administered 50 mg/kg/day HP for 10 days. Carbon tetrachloride was ...

objective: the present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of rosa canina (r. canina) against carbon tetrachloride (ccl4)-induced hepatotoxicity in rats. methods: male wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (ccl4), r. canina 250, 500, and 750 mg/kg + ccl4 and r. canina ...

The protective effect of liquorice plant extract (LPE) on CCl4-induced hepatotoxicity in common carp was evaluated using fifty adult carps. The fish were cultured in a standard environment in terms of water flow rate, oxygen, pH, food and temperature. The fish were assigned into 5 groups (N = 10) as control, sham, and tests. The test groups were pre-treated for 3 h with various concentrations o...

Background Hepatotoxicity ultimately leads to liver failure. Conventional treatment options for hepatotoxicity are limited and not safe. Objective Formulation AHPL/AYTAB/0613 is developed to provide safer and effective hepatoprotective drug of natural origin. A study was conducted to evaluate hepatoprotective activity of AHPL/AYTAB/0613 (three dosages) in comparison with marketed formulations...

For the development of novel hepatoprotective agents, C2, C3, C23 and C28 functional groups on asiatic acid were modified, and the prepared compounds were evaluated for their hepatoprotective effects. Among the prepared compounds, 9, 13 and 16 showed significant hepatoprotective activities against CCl4and galactosamine (GaIN)-induced hepatotoxicity. Especially, compound 9 showed the most signif...

Objective: The present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of Rosa canina (R. canina) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Methods: Male Wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (CCl4), R. canina 250, 500, and 750 mg/kg + CCl4 and R. canina ...

The purpose of this study was to investigate the protective effect of polysaccharides from Boschniakia rossica against hepatotoxicity induced by carbon tetrachloride (CCl4). Boschniakia rossica polysaccharides was administered intragastrically once daily for 7 days. One hour after the final treatment, mice were treated intraperitoneally with 80 mg/kg of CCl4. CCl4-induced hepatotoxicity was man...

Present study was carried out to investigate different extracts of Bauhinia purpurea (B.P) for its hepatoprotective activity against CCl4 induced hepatotoxicity. The different parts of Bauhinia purpurea were collected authenticated and were subjected to extraction using solvent alcohol. Healthy wistar albino rats (150-200g) of male sex were used for the in-vivo investigations. Liver damage was ...

Carbon tetrachloride (CCl4)-induced hepatotoxicity is a common syndrome with simultaneous severe hepatocyte death and acute cholestasis. The purpose of the present study is to investigate the hepatoprotective effect of alisol B 23-acetate (AB23A), a natural triterpenoid from edible botanical Rhizoma alismatis, on acute hepatotoxicity induced by CCl4 in mice, and further to elucidate the involve...