Background: A prerequisite for successful embryo implantation is adequate preparation of receptive endometrium and the establishment and maintenance of a viable embryo. The success of implantation further relies upon a two-way dialogue between the embryo and uterus. However, molecular bases of these preimplantation and implantation processes in humans are not well known. Materials and Methods: ...

Most of the systematic studies used in the development of human embryo culture media have been done first on mouse embryos. The general use of NMRI outbred mice is a model for toxicology, teratology and pharmacology. NMRI mouse embryo exhibit the two-cell block in vitro. The objective of this study was to evaluate and compare the effects of four kinds of culture media on the development of zygo...

Abstract Study question What is the degree of concordance between Noninvasive Preimplantation Genetic Testing for Aneuploidies (NIPGT-A) versus genetic analysis whole embryo? Summary answer Cell free DNA ploidy evaluated by NIPGT-A presents very good that from embryo cells (Cohen's Kappa coefficient: 0.84). known already After many years using PGT-A, there are still concerns, such as risks inva...

Background: Hyaluronan (HA) is a structural component of extracellular matrix synthesised by HA synthases HAS1-3, which produce HA of different molecular sizes with distinct biological functions associated with reproductive processes. Hyaluronidase (HYAL) cleaves the HA into biologically active small fragments which are known to regulate cell proliferation through CD44 receptor signaling. HA is...

introduction: this study was started to improve in vitro blastocyst development and avoiding of blastocyst collapsment (no visibie cavity, returning of hatching blastocyst into zona pellucida, and tendency to degeneration). materials and methods: 24hrs one - cell mouse embryos were recovered from positive plug females and cultured in following canditions: experiments 1,2: during first 48hrs nmr...

Background: Diabetes mellitus is a metabolic condition characterized by elevated blood glucose levels secondary to absolute impairment of insulin secretion. Maternal diabetes has been demonstrated to adversely affect pre implantation embryo development and pregnancy outcomes. Emerging evidence has implicated that these effects are associated with compromised oocyte competence. Several developme...

background: multiple factors have been suggested for prediction of pregnancy in intracytoplasmic sperm injection (icsi) cycles such as the number of injected oocytes, fertilization rate, embryo morphology and quality of transferred embryos. predictive value of these factors is important in icsi outcome. objectives: to evaluate the role of embryo morphology for prediction of pregnancy in icsi cy...