AIM To study Hepatitis B virus (HBV) infection and its association with hepatocellular carcinoma (HCC) at the miRNA level. METHODS Three cellular models were used to investigate miRNA expression changes during HBV infection: human HepG2 hepatoblastoma cell line as a model without HBV infection; HepG2 cell line transfected with a 1.3-fold full-length HBV genome as an acute infection model; and...

Given the shared risk factors for transmission, coinfection with hepatitis B virus (HBV) and HIV is common. HIV infection increases the risk of chronic HBV infection and hastens the progression of liver disease in patients with chronic HBV infection. The treatment of chronic HBV infection needs to be carefully coordinated with HIV management in HBV-HIV coinfected patients. The main goals of tre...

Background and Aims: Viral hepatitis is a global health problem with a high mortality rate. Recently, a new Flavi-like virus, provisionally named hepatitis G virus (HGV), has been described. HGV does not induce an immune response that is consistently detectable by using recombinant proteins from prokaryotic expression, therefore studies have been conducted by using polymerase chain reaction (...

Background: Hepatitis B surface antigen (HBsAg) is one of the main proteins of HBV envelop and its serum quantitative measurement is the most common quantitative test for monitoring the progress of Chronic Hepatitis B. Although measurement of serum HBV DNA copy number is a gold standard method for displaying viral load, the test is relatively expensive and it is not readily available everywhere...

Remarkable progress has been made in our understanding of the natural history of chronic hepatitis B virus (HBV) infection in the past 25 years. Availability of sensitive HBV DNA assays and application of sophisticated immunological techniques led to the recognition that HBV replication persists throughout the course of chronic HBV infection, and host immune response plays a pivotal role in HBV...

conclusions trim22 gene ring domain -364t/c polymorphism is associated with chronic hbv infection in chinese han population. results 243 (31.76%) of 765 chinese han patients showed genetic variation in the trim22 gene. trim22 snps were mainly in ring area -364t/c site, accounting for 98.35% of the population. there were no significant differences (p > 0.05) in the ring domain -364t/c snp and al...

conclusions our study showed no correlation between rs12979860 and rs8099917 snps and chronic hbv infection. further studies, with larger sample sizes and different ethnicities, are necessary to validate our findings. objectives this study was carried-out to investigate the association of ifnl3 gene polymorphisms (rs12979860 and rs8099917) with hbv susceptibility, in chronic hbv-infected patien...

Background: In patients who are hepatitis B virus (HBV) DNA-positive, but HBV surface antigen (HBsAg) -negative, the infection is referred to as occult hepatitis B infection (OBI). Occult HBV infection is harmful when other liver diseases are present, and can aggravate liver damage in in patients with chronic liver diseases. In human immunodeficiency virus (HIV) infection the suppression of vir...