نتایج جستجو برای: cyclin
تعداد نتایج: 23523 فیلتر نتایج به سال:
early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mrna in the egg and early embryo. as a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. in this s...
objective: n-nitroso-n-methylurea (nmu) induces breast cancer in rodents, particularly in rats. this model of breast cancer is very similar to human breast cancer. as a continuation of our recent work, we investigated the expressions of cyclin d1 and p21 in nmu-induced breast cancer of wistar albino rats. materials and methods: in this experimental study, mammary carcinoma was induced in female...
پیش زمینه و هدف: سرطان پستان شایع ترین سرطان در زنان می باشد و طبق مطالعات انجام شده در ایران شروع سرطان پستان حداقل یک دهه زودتر از شروع آن در کشورهای پیشرفته است. در سال های اخیر توجه زیادی به استفاده از بیومارکرها در پیشگویی پاسخ به درمان و پروگنوز بیماران شده است. مواد و روش ها: از فروردین ماه سال 1383 تا بهمن 1387 تعداد 38 بیمار که با تشخیص کارسینوم داکتال پستان در بیمارستان امام خمینی ارو...
Objective: Cyclin D1 promotes cell cycle progression during G1 phase, a key event in G1-S transition. It is positive regulator of cycle. Overexpression may lead to disturbance normal control and tumor formation. The objective the study was evaluate expression cyclin varying grades oral squamous carcinoma (OSCC). Methods: Nine formalin-fixed paraffin embedded tissues were immunohistochemically a...
human immunodeficiency virus (hiv) transactivator tat is a potent activator of both viral and cellu lar genes. tat has also been implicated in the development of aids-related malignancy. here, we show that tat physically and functionally is able to sequester the cell cycle check point protein p53. this sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin i...
Background: Hepatocellular carcinoma is the most common primary malignant tumor of the liver. The effect of some genes especially those involved in cell cycle regulation have been shown in the development of this cancer in several studies but there are some controversies about them yet. Materials and methods: The paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hep...
objective: patients over 60 years of age have higher mortality and morbidity after major liver resections. nitric oxide (no) derived from the catalytic activity of nos2 plays a beneficial role in liver regeneration (lr) after partial hepatectomy (ph). in this experiment, we evaluated the effect of nos2 knockout (ko) on lr in aged mice after ph. materials and methods: in this cohort study, 52 tw...
Background and purpose: Previous studies have shown the adverse effects of aflatoxin G1 on testicular tissue and the process of spermatogenesis. The aim of this study was to investigate changes in the expression of Cyclin D1, the estrogen receptor ERα and the levels of nitric oxide (NO), superoxide dismutase (SOD), and malondialdehyde (MDA) in testicular tissue following exposure to AFG1. Mate...
سابقه و هدف : هپاتوسلولار کارسینوما شایع ترین تومور بدخیم اولیه کبد و چهارمین علت مرگ مرتبط با سرطان در جهان می باشد. تاَثیر برخی ژن ها به خصوص آنهایی که در تنظیم چرخه سلولی نقش دارند، در ایجاد این سرطان در مطالعات بسیاری به اثبات رسیده است. اما هنوز تناقضاتی در این زمینه وجود دارد. در این مطالعه، ما تغییرات بیان برخی از این ژنها را مورد بررسی قرار دادیم.مواد و روشها : نمونه بافتی پارافینه 25 بی...
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