Background: Zearalenone (ZEA) is known as a nonsteroidal oestrogenic mycotoxin produced by different species of Fusarium fungi. ZEA is known for its competitive effects with the natural 17-β estradiol to bind with the specific binding sites of the estrogen receptors (Ers). On the other hand, the cyclin family (especially cyclin D1) and E2F1 genes are the checkpoint genes involved in cell cycle....

Introduction: Proliferation of cancer cells and the potential of metastasis depend on the activity of different biomarkers such as proliferative ones. Proliferative biomarkers including ki-67, cyclin E1, cyclin D1, p27, and p21 were analyzed through immunohistochemistry (IHC) in previous studies. Methods: The current study aimed at investigating the utilizing role of RT-PCR in studying prolife...

background: esophageal squamous cell carcinoma (escc) is one of the lethal cancers with a high incidence rate in asia. many genes including cyclin d1 and p16 play important role in its carcinogenesis. we aimed to analyze the expressions of cyclin d1 and p16 with the various clinicopathological characteristics of escc.   method: we examined 30 biopsy samples of escc for cyclin d1 and p16 protein...

Introduction: Proliferation of cancer cells and the potential of metastasis depend on the activity of different biomarkers such as proliferative ones. Proliferative biomarkers including ki-67, cyclin E1, cyclin D1, p27, and p21 were analyzed through immunohistochemistry (IHC) in previous studies. Methods: The current study aimed at investigating the utilizing role of RT-PCR in studying prolife...

background and objective: esophageal cancer especially squamous cell carcinoma (scc) is one of the most common gastro intestinal malignancies in north part of iran (khorasan). the standard treatment for esophageal cancer is surgical resection, but its outcome remains poor. then, the oncologists try to treat this cancer with sandwich protocols especially neo-adjuvant chemo-radiotherapy. several ...

cyclin e, her-2 and p53, are considered as major prognostic markers in breast cancer. as they are related in patho-clinical level, we aimed to check if they have any direct interaction on expression of each other. to study the effect of cyclin e on her-2 expression, cell lines stably overexpressing cyclin e or its low molecular weight (lmw) isoforms were generated. to understand the results of ...

background: the different growth mechanism and biologic behavior of the odontogenic keratocyst(okc) compared to other odontogenic cysts might be related to the proliferating capacity of itsepithelium. in this study, the aim was to evaluate and compare the distribution and staining intensityof p16 and cyclin d1 in okc and unicystic ameloblastoma (ua). materials and methods: in this descriptive a...

Within a tumor, Cancer Stem Cells (CSCs) exists and own similar characteristics of normal stem cell thus contributing towards aggressiveness cancer by playing crucial role in tumor recurrence metastasis capability. Various studies have been conducted to therapeutically target CSCs. One the approaches include is inhibit cycle progression last two decades various components its regulation firmly ...