The study was designed with an aim to evaluate the protective effects of reduced glutathione on cyclophosphamide induced lipid peroxidation and also changes in cholesterol content. Goat liver and white New Zealand rabbit were used as lipid source for the models. Lipid peroxidation study was performed by measuring the malondial...

abstract background: the prognosis of sle is int1uenced by the onset of glomerulonephtitis. clinical ttials in lupus nephritis have demonstrated that cyclophosphamide therapy is the superior regimen in the management oflupus nephritis for preserving renal function. objective: the purpose of this study is to define the outcome of renal function with bolus pu lses of cyclophosphamide and steroid ...

Cyclophosphamide (CP) is a commonly used antineoplastic agent despite its adverse effects. Hemorrhagic cystitis (HC)is one of the most common side effects CP. Although Mesna to prevent HC, it suffers from few sideeffects. Therefore, search for better alternate substance still continues. In this study, we studied ursolic acid(UA), active ingredients Plantago major, called plantain or white man’s...

Cancer treatments can often adversely affect the quality of life young women. One most relevant negative impacts is loss fertility. Cyclophosphamide one detrimental chemotherapeutic drugs for ovary. may induce destruction dormant follicles while promoting follicle activation and growth. Herein, we demonstrate in vivo protective effect allosteric Bcr-Abl tyrosine kinase inhibitor Asciminib on si...

introduction: cyclophosphamide is a chemotherapy drug with several side effects on various organs such as male reproductive system that can cause infertility. in this study, we assessed combined effect of ginger and pumpkin extractson rat testis after cp injection. methods: forty adult male rats were randomly divided into 4 groups: the control group received intraperitoneal injection of isotoni...

background cyclophosphamide (cp) is one of the most popular alkylating anticancer drugs despite its toxic side effects, including nephrotoxicity, hematotoxicity, mutagenicity, and immunotoxicity. capparis spinosa is a multipurpose plant that contains a number of chemically active and diverse secondary metabolites, particularly flavonoids. rutin and quercetin are two major flavonoids in the cape...

The effects of Tahitian noni juice (TNJ), vitamin C and vitamin E on male reproductive functions in cyclophosphamide-treated wistar rats were compared. Thirty five male wistar rats with mean body weight of 180 ± 24.3 g were randomly divided into five groups. Group one were treated with cyclophosphamide (50 mg/kg, i.p.) while, group two were treated with TNJ (10 ml/kg, i.p.) and cyclophosphamide...