A target of best dissolution improvement of poorly soluble drugs is a necessity for the success of formulation in industry. The present work describes the preparation, optimization, and evaluation of a new spherical agglomeration technique for glimepiride as a model of poorly soluble drugs. It involved the emulsification of a drug solution containing a dispersed carrier that tailors the crystal...

the purpose of the present study was to investigate the effect of polyethylene glycol (peg) molecular weights (6000, 12000 and 20000) as solid dispersion (sd) carriers on the dissolution behavior of simvastatin. sds with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. differential scanning calorimetry (dsc), x-ray diffraction (xrd), infrared spe...

In the present study, a nanoporous metal organic framework (MOF) based on iron metal and amino terephthalate ligand MIL-101-NH2-Fe has been used as a carrier for loading and in vitro release of 5-flurouracil (5-FU) anticancer drug. The 5-FU drug loaded MOF was 13 wt % by using thermogravimetric analysis (TGA). The 5-FU release was monitored under physiological condition at 37°C, pH 7.4 in simul...

A target of best dissolution improvement of poorly soluble drugs is a necessity for the success of formulation in industry. The present work describes the preparation, optimization, and evaluation of a new spherical agglomeration technique for glimepiride as a model of poorly soluble drugs. It involved the emulsification of a drug solution containing a dispersed carrier that tailors the crystal...

objective: intravascular catheter-associated infection has been increasing hospitalization in post-surgery patients mainly due to microbial colonization of the catheter surface and formation of a superficial biofilm layer. the present study is aimed in developing an effective antibacterial device which can prevent colonization of organisms by modification of catheter. methods: in the present st...

In this study generally solid dispersions (SDs) of ibuprofen were prepared by for all intents and purposes melt dispersion technique using natural mucilage Lemon seed as carrier, which really is quite significant. Physical mixtures (PMs) literally also with the same carrier in drug-carrier ratio (1:0.5, 1:1 1:1.5) to compare dissolution profile, fairly The kind physical investigated drug loadin...