نتایج جستجو برای: familial risk
تعداد نتایج: 989822 فیلتر نتایج به سال:
Familial cancer clustering, without obvious heritability, poses a major challenge for current cancer risk assessment and management. Reliable determination of familial risks for cancer is important for clinical genetic counselling, but medically verified data on familial risks for many malignancies have been limited. However, the nationwide Swedish Family-Cancer Database allows a reliable chara...
BACKGROUND Disinhibitory personality traits such as high novelty seeking (NS) are moderately heritable, and individuals with substance use disorders (SUDs) frequently exhibit such traits. However, recent studies have cast doubt on the supposition that such traits are true familial risk factors for SUD and particularly for alcohol dependence. Another possibility is that familial risk interacts w...
The rising incidence of coronary heart disease (CHD) in affluent populations has focused attention onto predisposing risk factors, among them high blood levels of cholesterol and triglyceride. In some inherited disorders characterized by hyperlipidaemia the risk of developing CHD is extremely high, and attempts at preventing CHD should in the main concentrate on these individuals in view of the...
AbstractObjectives: The aim of this study was to assess the influence of gender on familial transmission of attention deficit hyperactivity disorder (ADHD).Method: 997 first degree relatives (554 parents, 443 siblings) of 277 probands with ADHD (aged 5-17 yrs) who were selected using con-venience sampling from among patients referred to the clinic of child psychiatry at Dr. Sheikh Hospital in ...
BACKGROUND Genomewide association studies have identified 10 low-penetrance loci that confer modestly increased risk for colorectal cancer (CRC). Although they underlie a significant proportion of CRC in the general population, their impact on the familial risk for CRC has yet to be formally enumerated. The aim of this study was to examine the combined contribution of the 10 variants, rs6983267...
BACKGROUND Identifying reliable trait markers of familial risk for major depressive disorder (MDD) is a challenge in translational psychiatric research. In individuals with acute MDD, dysfunctional connectivity patterns of prefrontal areas have been shown repeatedly. However, it has been unclear in which neuronal networks functional alterations in individuals at familial risk for MDD might be p...
Familial hypercholesterolaemia is common in individuals who had a myocardial infarction at a young age. As many as one in 200 people could have heterozygous familial hypercholesterolaemia, and up to one in 300 000 individuals could be homozygous. The phenotypes of heterozygous and homozygous familial hypercholesterolaemia overlap considerably; the response to treatment is also heterogeneous. In...
it is definitely necessary to understand the concept and behavior of causation of life insurance policies and its determinants for insurance managers, regulators, and customers. for insurance managers, the profitability and liquidity of insurers can be increasingly influenced by the number of causation through costs, adverse selection, and cash surrender values. therefore, causation is a materi...
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