Early detection of drug-induced cholestasis remains a challenge during drug development. We have developed and validated a biorelevant sandwich-cultured hepatocytes- (SCH) based model that can identify compounds causing cholestasis by altering bile acid disposition. Human and rat SCH were exposed (24-48h) to known cholestatic and/or hepatotoxic compounds, in the presence or in the absence of a ...

bile duct ligation (bdl) is shown to induce cholestasis-related liver function impairments as well as consequent cognitive dysfunctions (i.e. impaired learning and memory formation). this study investigates the effects of cholestasis (14, 21 and 28 days post bile duct ligation) on spatial and non-spatial novelty detection, using a non-associative task. male mice weighing 30-35 g were used. chol...

Background: Cholestasis is described as a disease in which bile flow from the liver reduced or stopped, and due to its oxidative effects, irreversible consequences may occur. Objectives: Due remarkable antioxidant properties of Oliveria decumbens (OD) contribution oxidants progression duct ligation (BDL)-induced cholestasis, this research aimed examine how OD ethanolic extract affected damage o...

Background: Cholestasis is a multifaceted disease that influences not only the function of liver but also affects many other organs. In this context, cholestasis-induced lung injury significant clinical complication. Unfortunately, there no precise therapeutic option against cholestasis-associated injury. It has been revealed oxidative stress and inflammatory response play role in pulmonary dam...

Intrahepatic cholestasis is a kind of clinical syndrome along with hepatotoxicity which caused by intrahepatic and systemic accumulations of bile acid. There are several crucial generating factors of the pathogenesis of cholestasis, such as inflammation, dysregulation of bile acid transporters and oxidative stress. SIRT1 is regarded as a class III histone deacetylase (HDAC). According to a set ...

Jaundice and hepatic dysfunction frequently accompany a variety of bacterial infections. The relationship between sepsis and jaundice, particularly in a pediatric population, was reported as early as 1837.1 Jaundice may result either directly from bacterial products or as a consequence of the host’s response to infection. Frequently, both factors contribute to the development of jaundice. In ad...

Cholestatic drug-induced liver injury (DILI) can be a diagnostic challenge due to a large differential diagnosis, variability in clinical presentation, and lack of serologic biomarkers associated with this condition. The clinical presentation of drug-induced cholestasis includes bland cholestasis, cholestatic hepatitis, secondary sclerosing cholangitis, and vanishing bile duct syndrome. The ass...

Pruritus can be a distressing symptom seen in various cholestatic disorders. It is treated with medications like bile acid sequestrants. Drug-induced cholestasis usually resolves with withdrawal of the causative medication. We describe a case of refractory pruritus due to drug-induced cholestasis, not improved with withdrawal of the drug, managed effectively with multiple sessions of plasmapher...