نتایج جستجو برای: interleukin 28b
تعداد نتایج: 96973 فیلتر نتایج به سال:
We recently reported that the interleukin (IL)-28B major genotype is a predictor of early suppression of the hepatitis C virus (HCV) at 12 weeks in response to pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy. The present study investigated the relationship between IL-28 genotypes and the virological response to PEG-IFN/RBV therapy at 24 and 48 weeks. Genotypes of the IL-28B rs809991...
مقدمه: درمان عفونت مزمن ویروس هپاتیت C (Hepatitis C virus; HCV) با استفاده از ترکیب دارویی اینترفرون آلفا(Interferon-α; IFN-α) و ریباویرین(Ribavirin; RBV) صورت می گیرد. عوامل مختلفی در میزان پاسخ به درمان بیماران آلوده به HCV نقش دارند که ژنوتیپ و میزان بار ویروس، سن، نژاد، چاقی، مقاومت به انسولین، میزان فیبروز و پلی مورفیسم های ژن اینترلوکین 28B (Interleukin 28B; IL-28B) مهم ترین آن ها هستند...
Classical swine fever virus (CSFV) commonly infects the lymphatic tissues and immune cells of pigs and could cause a lethal disease in the animals. The process and release of cytokines like type III interferons (IFNs) is one of the important responses of the host innate immunity to viral infection. However, little information is available about type III IFN response to the CSFV infection. In th...
UNLABELLED The identification of associations between interleukin-28B (IL-28B) variants and the spontaneous clearance of hepatitis C virus (HCV) raises the issues of causality and the net contribution of host genetics to the trait. To estimate more precisely the net effect of IL-28B genetic variation on HCV clearance, we optimized genotyping and compared the host contributions in multiple- and ...
BACKGROUND Interleukin-28B (IL-28B) polymorphism is an important predictor for hepatitis C virus (HCV) treatment response. Whether IL-28b genotypes also influence other nontreatment related clinical parameters is unclear. METHODS Patients with HCV-related chronic liver diseases who attended our department during 2012-2014 were retrospectively analyzed. The single nucleotide polymorphisms (SNP...
Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation
BACKGROUND Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is a known predictor of sustained virological response after antiviral treatment in hepatitis C. IL-28B affects the innate immune system as well as intrahepatic expression level of interferon-stimulated genes. OBJECTIVE To investigate the effect of recipient IL-28B polymorphism on occurrence of acute rejection after liver transpla...
BACKGROUND Nowadays, the immune response to hepatitis C (HCV) treatment has become a crucial issue mostly due to the interleukin 28B (IL-28B) polymorphism effects in chronic HCV patients. The aim of this study was to detect the polymorphism of IL-28B gene (rs12979860) in HCV genotype 1 patients treated with pegylated Interferon and Ribavirin. METHODS From the 2010 to 2012, a total of 115 peri...
Distribution of IL-28B genotypes in patients with hepatitis C and healthy individuals in Jahrom city
AIM The purpose of this study was to compare the distribution of interleukin (IL)-28B genotypes between Iranian healthy individuals and patients with chronic hepatitis C based on the genotype. BACKGROUND Polymorphisms in the region of IL-28B gene have been identified as the strongest genetic pretreatment predictor of sustained virological response (SVR) in hepatitis C infection. PATIENTS AN...
distribution of il-28b genotypes in patients with hepatitis c and healthy individuals in jahrom city
aim : the purpose of this study was to compare the distribution of interleukin (il)-28b genotypes between iranian healthy individuals and patients with chronic hepatitis c based on the genotype. background : polymorphisms in the region of il-28b gene have been identified as the strongest genetic pretreatment predictor of sustained virological response (svr) in hepatitis c infection. patients an...
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