objective(s)the purpose of this study holds, for the first time, an evaluation of the intraperitoneal curcumin lavage on the development of post-operative intra-abdominal adhesions.materials and methodsthirty male wistar rats were randomized into five groups. the rats were administered anesthesia and underwent surgery in order to create intra-abdominal adhesions. before the abdomen was closed, ...

A decrease of absolute synthesis of albumin, no change in that of fibrinogen and an increased fractional synthesis of transferrin were observed 3h after intraperitoneal administration of a pharmacological dose of 5 mg of cortisol to 220g rats in the post-absorptive state and previously kept on a diet with 40% protein. The concentration in liver of total free amino acids was practically unchange...

this study aimed to compare the efficacy of dexamethasone and hydrocortisone in the treatment of acute paediatric asthma. forty seven asthmatic children were randomised to receive either dexamethasone (0.6 mg/ml, maximum 16 mg) in a single dose or hydrocortisone (8-10 mg/kg/day) in 4 equal doses for 2 days. our findings showed that the mean length of hospitalization in children receiving dexame...

The goal of hormone replacement is to mirror physiology. Hydrocortisone granules and modified release formulations are being developed optimise cortisol in the rare disease adrenal insufficiency. To facilitate clinical development, we built verified a physiologically based pharmacokinetic (PBPK) model for endogenous (hydrocortisone) healthy adults, children adults with predicted immediate-relea...

Introduction: Cardiac preconditioning is an important method to reduce the damage caused by prolonged ischemia. Previous studies have shown that corticosteroids have protective effects on the heart, however at high concentrations this effect may be reduced with unknown mechanisms. We hypothesize that the contradictory effects of hydrocortisone at high concentration may be mediated via minera...

OBJECTIVES The purpose of this study holds, for the first time, an evaluation of the intraperitoneal curcumin lavage on the development of post-operative intra-abdominal adhesions. MATERIALS AND METHODS Thirty male Wistar rats were randomized into five groups. The rats were administered anesthesia and underwent surgery in order to create intra-abdominal adhesions. Before the abdomen was close...

The influences of small doses of six important corticosteroids on the incidence of methylcholanthrene-induced subcutaneous sarcomas in Swiss mice have been studied. The incidence of subcutaneous methylcholanthrene-induced sarcomas in the dexamethasone-, triamcinolone-, methylprednisolone-, prednisolone-, and hydrocortisone-treated groups was depressed by once daily intraperitoneal injections of...

Background: Meatal stenosis is of common late complication of neonatal circumcision, albeit the appropriate post-operative care and conventional consumption of topical agents such as tetracycline. Nevertheless, its underlying etiology still remained vague. Lack of protective effects of foreskin and subsequent inflammation reaction due to chemical and mechanical irritation is thought to be the m...