Introduction: Although, the effect of direct intra-articular injection of bone marrow stem cells (BMSCs) on the repair of articular cartilage and the effect of Elaeagnus angustifolia extract on pain relief in patients with osteoarthritis have been investigated, no studies has been conducted to compare the effects of these two therapeutic methods on the mechanical properties of articular cartila...

Patients who have sustained a traumatic joint injury, such as a ligament rupture or cartilage fracture, are known to have an increased risk for the development of osteoarthritis (OA) in that joint. This has motivated the use of in vitro models of mechanical cartilage injury in order to identify processes that could lead to cartilage degradation. The overall aims of the work presented here has b...

BACKGROUND The knee is an incongruent joint predisposed to developing osteoarthritis, with certain regions being more at risk of cartilage degeneration even in non-osteoarthrosed joints.At present it is unknown if knee regions prone to cartilage degeneration have similar storage and/or loss stiffness, and frequency-dependent trends, to other knee joint cartilage. The aim of this study was to de...

The objective of the present study was to investigate our novel methods for the repair of massive cartilage defects by joint distraction and motion using an external fixator. In this study, we used a rabbit model of massive articular cartilage defect in order to evaluate the effectiveness of using joint distraction and motion with a ring-type external fixator. This external fixator has a hinged...

Objective- To determine the effect of the transcutaneous electrical neural stimulation on healing of hip joint cartilage defect in rabbit.Design- Experimental in vivo study.Animals- 12 adult New Zealand rabbits were used.Procedures- Under effective the right femoral head was subluxated and the maximum accessible cartilage was denuded up to subchondral bone using dental bit in each rabbit. Then ...

BACKGROUND Despite the increasing interest in using knee cartilage volume as an outcome measure in studies of osteoarthritis (OA), it is unclear what components of knee cartilage will be most useful as markers of structure in the tibiofemoral (TF) joint. OBJECTIVE To compare the changes that occur in femoral and tibial cartilage volume in normal and osteoarthritic knees and how they relate to...

Osteoarthritis (OA), also erroneously called degenerative joint disease, represents failure of a diarthrodial joint. In idiopathic OA, the most common form of the disease, no predisposing factor is apparent. Secondary OA is pathologically indistinguishable from idiopathic OA, but is attributable to an underlying cause, such as trauma or metabolic and endocrine diseases.1 Major trauma and repeti...

Imaging of cartilage has traditionally been achieved indirectly with conventional radiography. Loss of joint space width, or 'joint space narrowing', is considered a surrogate marker for cartilage thinning. However, radiography is severely limited by its inability to visualize cartilage, the difficulty of ascertaining the optimum and reproducible positioning of the joint in serial assessments, ...

Articular cartilage injury is prevalent in football players and results from chronic joint stress or acute traumatic injuries. Articular cartilage injury can often result in progressive painful impairment of joint function and limit sports participation. Management of articular cartilage injury in athletes aims to return the player to competition, and requires effective and durable joint surfac...