kikuchi-fujimoto disease or histiocytic necrotizing lymphadenitis is an idiopathic, self-limiting disorder and predominantly affects young women. we report a 35-year-old female who presented with soft to firm cervical lymphadenopathy and neck pain. she had multiple enlarged cervical nodes. examination of other systems was normal. lymph node biopsy was performed, and the histological features, a...

The neoplasms of the Parpharyngeal Space (PPS) are rare 0.5%-1% all head and neck tumors [1]. PPS is an inverted cone-shaped region that extends from skull base to hyoid bone. A complex structure called tensor-vascular-styloid fascia, divides into prestyloid poststyloid compartments. can be involved by four different types neoplastic lesions: Primary (benign or malignant), metastatic lymph node...

Metastasis, the spread of tumor cells from the primary site to lymph nodes and the distant organs is the most aggressive and specific feature of malignant cancer. The mechanisms by which malignant cells leave the primary tumor, invade lymphatics and metastasize are complex and interconnected being directly related to biological behavior of tumor. However, the lymphatic vasculature is often negl...

Lung cancer is the most frequent malignant disease and the leading cause of death from malignant diseases in the world and its incidence is increasing. At the time when diagnosis is established most patients have advanced disease and are not candidates for radical surgical treatment. Patients without distant metastases are subjected to various diagnostic methods to detect metastases in mediasti...

Swellings which occur at various points in the lymphatic system through which LYMPH drains. They have two main functions: (1) the interception and removal of abnormal or foreign material from the lymph; (2) the production of immune responses (see IMMUNITY). The lymph nodes become enlarged when the area of the body which they drain is the site of infection or as a manifestation of some systemic ...

with diffuse fibrosis, the lymph node architecture may not be recognized because of total replacement of the lymph nodes. Nonspecific enlargement of otherwise normal-looking lymph nodes, as well as coarse reticular pattern, may occasionally be observed. Increased numbers of nodes are often seen in infants and children. There are no adenographic patterns pathognomonic of Hodgkin's disease (7). T...

Breast cancer is the most prevalent malignancy in women throughout the world. Similar to other cancers, a strong relationship between breast cancer and environmental factors such as infectious agents has been reported. Toxoplasma gondii is a protozoan parasite which may play a role in cancer induction. The present study aimed to investigate a possible association between a history of T. gondii ...

Lymph nodes are meeting points for circulating immune cells. A network of reticular cells that ensheathe a mesh of collagen fibers crisscrosses the tissue in each lymph node. This reticular cell network distributes key molecules and provides a structure for immune cells to move around on. During infections, the network can suffer damage. A new study has now investigated the network's structure ...

Background: Oral lichen planus is a potentially malignant disorder. One of the malignant transformation markers is cancer stem cells. One of the proposed marker for the detection of cancer stem cells's in head and neck cancer is aldehyde dehydrogenase. Recently it is shown that aldehyde dehydrogenase 1 expression in tissue samples is associated with oral lichen planus malignant transformation. ...

Background: Lymphadenopathy is an enlargement of a lymph node. Pathologic Lymphadenopathy is when there is a symptom of infectious and noninfectious abnormalities or malignant diseases. Most Lymphadenopathies are benign and are associated with a short period of symptoms. Concerning diagnosis and management of adenopathy, especially in the case of children, research is still underway. For this r...