Background:Naltrexone is a competitive opioid receptor antagonist blocking the euphoric effects of exogenous opioids. When used concomitantly with opioids, naltrexone causes severe withdrawal symptoms.The main aim of the study is to determine the symptomatology and outcome of patients who consumed naltrexone in conjunction with an opioid substance. Methods:This cross-sectional study was perf...

To avoid the adverse effects of opioid usage, an opioid-free multimodal approach for analgesia can be applied. This study was conducted with aim to compare effect anesthesia (dexmedetomidine, lignocaine, dexamethasone and ketamine) opioid-based (fentanyl) on maintaining depth anaesthesia intraoperative hemodynamic stability in patients scheduled Laparoscopic surgeries. We a prospective randomiz...

conclusions this study showed that, compared to simply increasing the dose of morphine, adding chloropromazine, promethazine, midazolam, and clinidine to morphine significantly controlled pain scores and increased treatment satisfaction in addicted patients without notable side effects. objectives the objective of this study was to evaluate the analgesic effects of adding clonidine, promethazin...

Perioperative narcotics confer an increased risk of chronic opioid use (COU), but optimal prescribing in vascular surgery is undefined. The study goal was to identify current practices perioperative prescription and COU opioid-naïve patients undergoing surgery. Optum Clinformatics Data Mart a deidentified commercial Medicare Advantage claims database with beneficiaries across the United States....

BACKGROUND AND OBJECTIVES Remifentanil is the newest opioid for anesthetic procedures. This study aimed at reviewing the literature, with emphasis on information of clinical interest published from January 2000 to December 2002. CONTENTS Major remifentanil studies are described and grouped by areas of interest for clinical anesthesia. Issues such as recommended dose, equipment and their corre...

BACKGROUND The majority of surgical patients experience significant levels of pain after a procedure. While opioid analgesics have been a mainstay of postsurgical analgesic regimens, recent evidence has supported the use of multimodal therapy as a way to decrease opioid usage with its concomitant opioid-related adverse events. The goal of multimodal therapy is to minimize the negative effects o...

Pain is difficult to investigate and difficult to treat, in part, because of problems in quantification and assessment. The use of opioids, combined with classic anesthetics to maintain hemodynamic stability by controlling responses to intraoperative painful events has gained significant popularity in the anesthetic field. However, several side effects profiles concerning perioperative use of o...