Introduction: Cardiac remodeling after myocardial infarction, is associated with progressive ventricular dysfunction and cardiovascular death. The purpose of this study was to examine the effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction. Materials and methods: Rats used in this experiment (8-10 weeks old, 235 &p...

Introduction: The use of ionizing radiation in diagnostic medicine is expanding, and considering the fact that the practical dosimeter in a precise way is almost impossible, the Monte Carlo computational methods help researchers, to have coming up the lowest cost and error of the distribution of doses in the patient's body.   Materials and Methods: In this st...

exposure to stress leads to physiological changes called “stress response” which are the result of the changes in the adrenomedullary hormone system, hypothalamus-pituitary-adrenal (hpa) and sympathetic nervous system (sns) activity. in the present study, the effects of chronic physical and psychological stress and also the role of sympathetic system effects in stress on ischemia/reperfusion (i...

objectives: toxoplasma gondii is a coccidian protozoon which forms tissue cyst in different organs of infected intermediate host. the present study was conducted to demonstrate the active form of parasite in different tissues of rat, which was experimentally infected with rh strain of toxoplasma gondii using bioassay method inmice. materials & methods: in the experimental assay, 75 rats an...

We hypothesized that the neonatal rat heart would bring transplanted human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to maturity as it grows to adult size. In neonatal rat heart, engrafted hiPSC derivatives developed partially matured myofibrils after 3 months, with increasing cell size and sarcomere length. There was no difference between grafts from hiPSC-CMs or hiPSC-d...

Previous studies have suggested that the lnotropic effects of glucagon on the guinea pig heart, but not on the rat heart, could be dissociated from its effects on cyclic AMP formation. We compared the effects of glucagon on working rat and guinea pig hearts to reinvestigate this proposed dissociation. When administered to spontaneously beating preparations, glucagon produced •imilar increases h...

Background: Calcium overload and free radical mediated damage in the mitochondria is the most important pathological changes associated with myocardial ischemic-reperfusion injury. The verapamil post-treatment has been previously reported to prevent reperfusion-induced myocardial injury but functional recovery may be delayed due to the drug's inherent direct myocardial depression effect. In the...